Nepicastat HCl DBH inhibitor

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Catalog No. A11172

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Nepicastat hydrochloride 5mg A11172-5
$60.00
Nepicastat hydrochloride 10mg A11172-10
$100.00
Nepicastat hydrochloride 50mg A11172-50
$300.00
Nepicastat hydrochloride 100mg A11172-100
$500.00
Nepicastat HCl 10mM * 1mL in DMSO A11172-10mM-D
$99.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Nepicastat HCl

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Chemical Information

Catalog Num A11172
Actions Inhibitor
M. Wt 331.81
Formula C14H15F2N3S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 170151-24-3
Synonyms RS-25560-197, SYN117
SMILES code C1CC2=C(C=C(C=C2C[[email protected]]1N3C(=CNC3=S)CN)F)F.Cl
Chemical Name 5-(Aminomethyl)-1-[5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2(S)-yl]-2,3-dihydro-1H-imidazole-2-thione hydrochloride

Biological Activity

Description

Nepicastat hydrochloride is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

Targets
Bovine dopamine-beta-hydroxylase Human dopamine-beta-hydroxylase
8.5 nM9 nM

Solubility

Solubility (25°C)* In vitro DMSO 66 mg/mL (198.9 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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