NVP-AEW541

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IGF-1R inhibitor

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Catalog No. A11021

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
NVP-AEW541 2mg A11021-2

Regular Price: $80.00

Special Price: $68.00

NVP-AEW541 5mg A11021-5

Regular Price: $120.00

Special Price: $102.00

NVP-AEW541 10mg A11021-10

Regular Price: $150.00

Special Price: $127.50

NVP-AEW541 25mg A11021-25

Regular Price: $300.00

Special Price: $255.00

NVP-AEW541 10mM * 1mL in DMSO A11021-10mM-D

Regular Price: $110.00

Special Price: $93.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

NVP-AEW541

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Chemical Information

Catalog Num A11021
Actions Inhibitor
M. Wt 439.6
Formula C27H29N5O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 475489-16-8
Synonyms AEW541
SMILES code C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
Chemical Name 7-​[cis-​3-​(1-​azetidinylmethyl)cyclobutyl]-​5-​[3-​(phenylmethoxy)phenyl]-​7H-​pyrrolo[2,​3-​d]pyrimidin-​4-​amine

Biological Activity

Description
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).

Solubility

Solubility (25°C) * In vitro DMSO 88 mg/mL (200.2 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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