NVP-AEW541

Catalog No.: A11021
IGF-1R inhibitor
NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
Grouped product items
Product Name Price Stock Qty
NVP-AEW541 2mg
$80.00
In stock
NVP-AEW541 5mg
$120.00
In stock
NVP-AEW541 10mg
$150.00
In stock
NVP-AEW541 25mg
$300.00
In stock
NVP-AEW541 10mM * 1mL in DMSO
$110.00
In stock
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Adooq Products cited in reputable paper
Adooq's NVP-AEW541 has been cited by 3 publications
  • Deep R Sharma, .et al. , Cereb Cortex, 2023, Jan 16 PMID: 36646459
  • Ashalyn P Watt, .et al. , Cell Tissue Res, 2021, Jan 13 PMID: 33439347
  • Tsushima H, .et al. , Autoimmunity, 2017, Aug;50(5):329-335 PMID: 28682648
  • Biological Activity
    Discription NVP-AEW541 is a selective IGF-1R kinase inhibitor that inhibits the autophosphorylation activity of IGF-1R (IC50 = 0.086 uM) and prevents IGF-1-mediated survival and proliferation of MCF-7 cells (IC50 = 0.16 and 1.64 uM, respectively).
    Product Information
    Catalog Num A11021
    Formula C27H29N5O
    Molecular Weight 439.6
    CAS Number 475489-16-8
    SMILES C1CN(C1)CC2CC(C2)N3C=C(C4=C3N=CN=C4N)C5=CC(=CC=C5)OCC6=CC=CC=C6
    Synonyms AEW541
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 77 mg/mL (175.18 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 19 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.75 mL 113.74 mL 227.48 mL
    0.5 mM 4.55 mL 22.75 mL 45.5 mL
    1 mM 2.27 mL 11.37 mL 22.75 mL
    5 mM 0.45 mL 2.27 mL 4.55 mL
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