PD 0332991 HCl (Palbociclib)

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CDK 4/6 inhibitor

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Catalog No. A10701

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD 0332991 HCl 5mg A10701-5

Regular Price: $50.00

Special Price: $42.50

PD 0332991 HCl 10mg A10701-10

Regular Price: $70.00

Special Price: $59.50

PD 0332991 HCl 25mg A10701-25

Regular Price: $85.00

Special Price: $72.25

PD 0332991 HCl 50mg A10701-50

Regular Price: $100.00

Special Price: $85.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.

PD 0332991 HCl (Palbociclib)

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Chemical Information

Catalog Num A10701
Actions Inhibitor
M. Wt 447.5
Formula C24H29N7O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 827022-32-2
Synonyms N/A
SMILES code CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.Cl
Chemical Name Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-acetyl-8-cyclopentyl-5-methyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, monohydrochloride

Biological Activity

Description
PD 0332991 HCl is an orally available pyridopyrimidine-derived cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity.
Targets
Target Value
CDK4/CyclinD3IC50: 9nM
CDK4/CyclinD1IC50: 11nM
CDK6/CyclinD2IC50: 15nM
CDK2/CyclinE2IC50: >10μM
CDK2/CyclinAIC50: >10μM
CDK1/CyclinBIC50: >10μM
CDK5/p25IC50: >10μM
EGFRIC50: >10μM
FGFRIC50: >10μM
PDGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
VEGFRIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
CK1IC50: >10μM
CK2IC50: >10μM
c-SrcIC50: >10μM
GSK-3βIC50: >10μM
MAPK2/ERK2IC50: >10μM
MAPKAPK2IC50: >10μM
PKBIC50: >10μM
PKCIC50: >10μM
PHKIC50: >10μM
SAPK2aIC50: >10μM
SAPK3IC50: >10μM
SAPK4IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 3 mg/mL (6.19 mM)
Water 30 mg/mL (61.98 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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