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PD 0332991 Isethionate

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CDK4/6 inhibitor

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Catalog No. A13811

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD 0332991 Isethionate 10mg A13811-10

Regular Price: $70.00

Special Price: $63.00

PD 0332991 Isethionate 25mg A13811-25

Regular Price: $110.00

Special Price: $99.00

PD 0332991 Isethionate 50mg A13811-50

Regular Price: $140.00

Special Price: $126.00

PD 0332991 Isethionate 10mM * 1mL in DMSO A13811-10mM-D

Regular Price: $60.00

Special Price: $54.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD 0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively.

PD 0332991 Isethionate

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Chemical Information

Catalog Num A13811
Actions Inhibitor
M. Wt 483.99
Formula C24H30ClN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 827022-33-3
Synonyms PD0332991, PD-0332991
SMILES code CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C.C(CS(=O)(=O)O)O
Chemical Name 6-acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride

Biological Activity

Description
PD 0332991 Isethionate is a highly selective inhibitor of CDK4/6 with IC50 of 11 nM/16 nM respectively.
Targets
Target Value
CDK4/CyclinD3IC50: 9nM
CDK4/CyclinD1IC50: 11nM
CDK6/CyclinD2IC50: 15nM
CDK2/CyclinE2IC50: >10μM
CDK2/CyclinAIC50: >10μM
CDK1/CyclinBIC50: >10μM
CDK5/p25IC50: >10μM
EGFRIC50: >10μM
FGFRIC50: >10μM
PDGFRIC50: >10μM
Insulin ReceptorIC50: >10μM
VEGFRIC50: >10μM
AMPKIC50: >10μM
Chk1IC50: >10μM
c-SrcIC50: >10μM
GSK-3βIC50: >10μM
MAPK2/ERK2IC50: >10μM
MAPKKIC50: >10μM
p70S6KIC50: >10μM
PKBIC50: >10μM
PKCIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 50 mg/mL heating (87.15 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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