PD153035 (HCl salt) EGFR inhibitor

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Catalog No. A10702

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PD153035 10mg A10702-10
$50.00
PD153035 50mg A10702-50
$220.00
PD153035 100mg A10702-100
$380.00
PD153035 200mg A10702-200
$630.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.

PD153035 (HCl salt)

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Chemical Information

Catalog Num A10702
Actions Inhibitor
M. Wt 396.7
Formula C16H14BrN3O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 183322-45-4
Synonyms ZM 252868, AG 1517, Tyrphostin AG 1517, SU 5271, PD-153035
SMILES code COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br)OC.Cl
Chemical Name N-(3-Bromophenyl)-6,7-dimethoxy-4-quinazolinamine hydrochloride

Biological Activity

Description
PD153035 is an extremely potent and specific inhibitor of the tyrosine kinase activity of EGFR.
Targets
EGFR (Cell-free assay) EGFR (Cell-free assay)
5.2 pM(Ki)5.2 pM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 0.5 mg/mL (1.26 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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