PF-04449913

Smoothened inhibitor

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Catalog No. A13881

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF-04449913 5mg A13881-5
$90.00
PF-04449913 10mg A13881-10
$160.00
PF-04449913 25mg A13881-25
$320.00
PF-04449913 10mM * 1mL in DMSO A13881-10mM-D
$126.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.

PF-04449913

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Chemical Information

Catalog Num A13881
Actions Inhibitor
M. Wt 374.18
Formula C21H22N6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1095173-27-5
Synonyms PF-4449913,PF04449913
SMILES code CN1CC[[email protected]](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N
Chemical Name 1-((2R,4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea

Biological Activity

Description
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.
Targets
Smoothened
5 nM

Solubility

Solubility (25°C)* In vitro DMSO 47 mg/mL (125.52 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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