PF 4981517

CYP3A4 inhibitor

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Catalog No. A12544

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PF 4981517 5mg A12544-5

Regular Price: $80.00

Special Price: $64.00

PF 4981517 10mg A12544-10

Regular Price: $140.00

Special Price: $112.00

PF 4981517 25mg A12544-25

Regular Price: $280.00

Special Price: $224.00

PF 4981517 50mg A12544-50

Regular Price: $500.00

Special Price: $400.00

PF 4981517 10mM * 1mL in DMSO A12544-10mM-D

Regular Price: $132.00

Special Price: $105.60

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).

PF 4981517

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Chemical Information

Catalog Num A12544
Actions Inhibitor
M. Wt 456.59
Formula C26H32N8
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1390637-82-7
Synonyms PF4981517, PF-4981517
SMILES code CC1=CC=C(C=C1)C2=C(C=NN2C)C3=NN(C4=C3C(=NC=N4)N5CC[[email protected]@H](C5)N6CCCCC6)C
Chemical Name (1-Methyl-3-[1-methyl-5-(4-methylph?enyl)-1H-pyrazol-4-yl]-4-[(3S)-3-piperidin-1-ylpyr?rolidin-1-yl]-1H-pyrazolo[3,4-d]pyrimidine)

Biological Activity

Description
PF 4981517 is a potent and selective inhibitor of CYP3A4 (IC50 values are 0.03, 17 and 70 μM for CYP3A4, CYP3A5 and CYP3A7 respectively).
Targets
CYP3A4
30 nM

Solubility

Solubility (25°C)* In vitro DMSO 91 mg/mL (199.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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