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PFI-2

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SETD7 inhibitor

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Catalog No. A14216

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PFI-2 10mg A14216-10

Regular Price: $100.00

Special Price: $80.00

PFI-2 25mg A14216-25

Regular Price: $200.00

Special Price: $160.00

PFI-2 50mg A14216-50

Regular Price: $350.00

Special Price: $280.00

PFI-2 10mM * 1mL in DMSO A14216-10mM-D

Regular Price: $105.00

Special Price: $84.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

PFI-2

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Chemical Information

Catalog Num A14216
Actions Inhibitor
M. Wt 499.52
Formula C23H25F4N3O3S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1627676-59-8
Synonyms PFI2
SMILES code C1CCN(C1)C(=O)[[email protected]@H](CC2=CC(=CC=C2)C(F)(F)F)NS(=O)(=O)C3=CC(=C4CNCCC4=C3)F
Chemical Name 8-fluoro-1,2,3,4-tetrahydro-N-[(1R)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide

Biological Activity

Description
PFI-2 is a potent, selective, and cell-active lysine methyltransferase SETD7 inhibitor with Ki (app) and IC50 of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
Targets
SETD7 SETD7
0.33 nM(Ki)2 nM

Solubility

Solubility (25°C)* In vitro DMSO 99 mg/mL (198.19 mM)
Water 4 mg/mL heating (8.0 mM)
Ethanol 66 mg/mL heating (132.12 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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