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Fig. 1 · Structure
Cat. No.
A11164
CAS No.
845714-00-3
Formula
C12H11N3O
Mol. Weight
213.24

Documents & Downloads

PHA-767491

Cat. No. A11164 CAS 845714-00-3

Cdc7/cdk9 inhibitor

PHA-767491 is a potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication.

In Stock

Publications for PHA-767491

2 publications citing this product

  1. Lei Tan, .et al. , Res Vet Sci, 2022, 145: 125-134 PMID: 35190327
  2. Qi Li, .et al. , Transl Oncol, 2018, Apr; 11(2): 300-306 PMID: 29413763
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For laboratory research use only. We do not sell to patients.

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Biological Activity

Target & Activity

Target Activity Value
CDK9 IC50 34 nM
CDK2 IC50 240 nM
CDK1 IC50 250 nM
CDK5 IC50 460 nM
GSK3-β IC50 220 nM
Mk2 IC50 470 nM
Plk1 IC50 980 nM
Chk2 IC50 1100 nM

8 targets · Scroll to view more

Cellular Effect

Cell Line Activity Value Description Reference
A2780 IC50 1.07 μM Antiproliferative activity against human A2780 cells expressing p53 gene after 72 hrs by proliferative assay [PMID: 18469809]
A2780 IC50 1.1 μM Antiproliferative activity against human A2780 cells after 72 hrs by luciferase based assay [PMID: 19115845]
A2780 IC50 1.1 μM Antiproliferative activity against human A2780 cells after 72 hrs [PMID: 18201066]
COLO 205 IC50 1.5 μM Antiproliferative activity against human COLO205 cells after 72 hrs by luciferase based assay [PMID: 19115845]
COLO 205 IC50 1.54 μM Antiproliferative activity against p53 deficient human COLO205 cells after 72 hrs [PMID: 18469809]
HCT-116 IC50 0.97 μM Antiproliferative activity against human HCT116 cells expressing p53 gene after 72 hrs by proliferative assay [PMID: 18469809]
HCT-15 IC50 3.81 μM Antiproliferative activity against human HCT15 cells expressing p53 gene after 72 hrs by proliferative assay [PMID: 18469809]
HeLa IC50 1.83 μM Antiproliferative activity against p53 deficient human HeLa cells after 72 hrs [PMID: 18469809]
HT-29 IC50 5 μM Antiproliferative activity against human HT-29 cells after 72 hrs by luciferase based assay [PMID: 19115845]
Jurkat IC50 3.2 μM Antiproliferative activity against p53 deficient human Jurkat cells after 72 hrs by proliferative assay [PMID: 18469809]
K562 IC50 5.87 μM Antiproliferative activity against p53 deficient human K562 cells after 72 hrs [PMID: 18469809]
L-363 IC50 1.6 μM Antiproliferative activity against human L363 cells after 72 hrs by luciferase based assay [PMID: 19115845]
MCF7 IC50 1.3 μM Antiproliferative activity against human MCF7 cells after 72 hrs by luciferase based assay [PMID: 19115845]
MCF7 IC50 1.33 μM Antiproliferative activity against human MCF7 cells expressing p53 gene after 72 hrs by proliferative assay [PMID: 18469809]
NCI-H929 IC50 1.8 μM Antiproliferative activity against human NCI-H929 cells after 72 hrs by luciferase based assay [PMID: 19115845]
NHDF IC50 1.58 μM Antiproliferative activity against NHDF expressing p53 gene after 72 hrs by proliferative assay [PMID: 18469809]
NHDF IC50 1.6 μM Antiproliferative activity against human NHDF cells after 72 hrs by luciferase based assay [PMID: 19115845]
OPM-2 IC50 4.5 μM Antiproliferative activity against human OPM2 cells after 72 hrs by luciferase based assay [PMID: 19115845]
OVCAR-8 IC50 1.56 μM Antiproliferative activity against p53 deficient human OVCAR8 cells after 72 hrs by proliferative assay [PMID: 18469809]
PC-3 IC50 4.59 μM Antiproliferative activity against human PC3 cells expressing p53 gene after 72 hrs by proliferative assay [PMID: 18469809]

20 records · Scroll to view more

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 845714-00-3
Applications Cdc7/cdk9 inhibitor
Formula C12H11N3O
Molecular Weight 213.24
SMILES
C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Publications

2 publications citing this product

  1. Lei Tan, .et al. , Res Vet Sci, 2022, 145: 125-134 PMID: 35190327
  2. Qi Li, .et al. , Transl Oncol, 2018, Apr; 11(2): 300-306 PMID: 29413763

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