PHA-793887

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CDK Inhibitor

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Catalog No. A10716

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PHA-793887 5mg A10716-5
$90.00
PHA-793887 10mg A10716-10
$150.00
PHA-793887 50mg A10716-50
$450.00
PHA-793887 100mg A10716-100
$750.00
PHA-793887 10mM * 1mL in DMSO A10716-10mM-D
$110.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.

PHA-793887

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Chemical Information

Catalog Num A10716
Actions Inhibitor
M. Wt 361.5
Formula C19H31N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 718630-59-2
Synonyms PHA793887
SMILES code CC(C)CC(=O)NC1=NNC2=C1CN(C2(C)C)C(=O)C3CCN(CC3)C
Chemical Name 3-Methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]butanamide

Biological Activity

Description
PHA-793887, a novel potent inhibitor of Cdk, target on kinds of cyclin-dependent kinase under low concentrations and poses high activity against several cancer cell lines.
Targets
Target Value
CDK5/p25IC50: 5nM
CDK2/CyclinAIC50: 8nM
CDK2/CyclinEIC50: 8nM
CDK7/CyclinHIC50: 10nM
CDK1/CyclinBIC50: 60nM
CDK4/CyclinD1IC50: 62nM
GSK-3βIC50: 79nM
CDK9/CyclinT1IC50: 138nM

Solubility

Solubility (25°C) * In vitro DMSO 72 mg/mL (199.18 mM)
Water <1 mg/mL (<1 mM)
Ethanol 72 mg/mL (199.18 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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