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|Storage||at -20°C 2 years|
|SMILES code||CC[C@@H]([C@@H](C)[C@@H]1[[email protected]](O1)C[[email protected]](C)/C=C/C=C(C)/[C@@H]2[[email protected]](/C=C/[C@ @H]([C@](CC[[email protected]](CC(=O)O2)O)(C)O)OC(=O)C)C)O|
|Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.|
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