Pladienolide B

Name: Pladienolide B
Brand: Adooq Bioscience
SKU: A12699
Rating: 5 (1 reviews)

Catalog No.: A12699

Adooq's Pladienolide B has been cited by 1 publications

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

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Grouped product items
Size	Price	Stock
100µg	$150.00	In stock
500µg	$495.00	In stock
1mg	$795.00	In stock
2mg	$1,495.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Adooq Products cited in reputable paper

Adooq's Pladienolide B has been cited by 1 publications

Biying Sun, .et al. , Plant Cell, 2024, Sep 3;36(9):3729-3750 PMID: 38941447

Biological Activity

Description	Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

Product Information

Catalog Num	A12699
Formula	C30H48O8
Molecular Weight	536.7
CAS Number	445493-23-2
SMILES	O[C@H]1CC(O[C@H](/C(C)=C/C=C/[C@@H](C)C[C@@H]2[C@]([C@H](C)[C@H](CC)O)([H])O2)[C@@H](C)/C=C/[C@H](OC(C)=O)[C@](C)(O)CC1)=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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