Natural Products

Dihydrotanshinone I, isolated from Salvia miltiorrhiza, exhibited cytotoxicity against various tumor cell lines.

Lysionotin, extracted from Ocimum basilicumL.

Ursolic acid(Malol) is a pentacyclic triterpene acid, used in cosmetics, that is also capable of inhibiting various types of cancer cells by inhibiting the STAT3 activation pathway and human fibrosarcoma cells by reducing the expression of matrix metalloproteinase-9 by acting through the glucocorticoid receptor.

Gossypol is a polyphenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes.

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.

Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.

ISalvianolic acid A (Sal A) and salvianolic acid B (Sal B) were isolated and purified from the crude extract of Salvia miltiorrhiza.

Myricitrin is the 3-O-rhamnoside of myricetin. Myricitrin is used by several beetle species in their communication system.

Glycitein is an O-methylated isoflavone which accounts for 5-10% of the total isoflavones in soy food products.

Glycitin is a natural isoflavone isolated from legumes, including soy and kudzu.

Bergenin (Cuscutin) is an isocoumarin isolated from various medicinal plants. Shows mild anti-HIV activity, antihepatotoxic activity and antiulcer activity.

Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation.

Pladienolide B is the major analogue of a family of macrocyclic lactones isolated from Streptomyces platensis. Pladienolide B is a highly potent inhibitor of both hypoxia signals and cancer cell proliferation. Pladienolide B binds to SF3b complex blocking the spliceosome.

Ginsenoside Rb1 is part of a class of steroid glycosides, and triterpene saponins, found exclusively in the plant genus Panax (ginseng).

Ligustilide, a main lipophilic component of Danggui (Chinese Angelica root, Radix Angelica sinensis), alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.

Neochlorogenic acid is a natural polyphenolic compound found in some types dried fruits and a variety of other plant sources such as peach

Dynemicin A is an antitumor natural product isolated from Micromonospora chersina which causes DNA strand cleavage.

20-Hydroxyecdysone is an ecdysteroid hormone produced in arthropod species that induces developmental changes associated with ecdysis and the completion of metamorphosis.

alpha-Cyperone is extracted from Cyperus rotundus L. dried rhizome.

Oxymatrine (Matrine N-oxide) is one of components of the root of Sophora flavescens.

Polydatin protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation. In addition, polydatin inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide; it also attenuates adhesion between white blood cells and endothelial cells.

Procyanidin B3 is a B type proanthocyanidin. Procyanidin B3 is a catechin dimer. It can be found in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho. It has been identified as an hair-growth stimulant

Chimaphilin is extracted from pyrola [Passiflora incarnata Fisch.] Chimaphilin could inhibit the viability of MCF-7 cells in a concentration-dependent manner, and the IC50 value was 43.30μM for 24h.

Glycyrrhizic acid is a widely used anti-inflammatory agent isolated from the licorice root.

Liquiritin is a flavonoid isolated from Glycyrrhiza, acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity.

Isoliquiritin is found in fruits. Isoliquiritin is isolated from Glycyrrhiza species Isoliquiritin has been shown to exhibit anti-depressant function.

Punicalagin is an ellagitannin, a type of phenolic compounds. It is a highly active carbonic anhydrase inhibitor.

Gramine is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many organisms. It is used mostly in synthetic organic chemistry as a starting material for tryptophan syntheses.

Hordenine is a phenethylamine alkaloid with antibacterial and antibiotic properties.

Proscillaridin A is a cardiac glycoside first isolated from plants in the genus Scilla.

Harmine hydrochloride, a fluorescent harmala alkaloid and CNS stimulant, from Santa Cruz.

Chlorogenic acid is an important intermediate in lignin biosynthesis. This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.

(-)Epicatechin gallate is a polyphenol apoptosis inducer in tumor cells commonly found in green tea.

(-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1

Lentinan is an intravenous anti-tumor polysaccharide and one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.

Scutellarin is a flavonoid that exhibits a number of cardio- and neuro-protective effects.

FR901464 is a potent anticancer natural product that lowers the mRNA levels of oncogenes and tumor suppressor genes.

Sesamin is a lignan isolated from the bark of Fagara plants and from sesame oil.

Pectolinarigenin is a Cirsium isolate with anti-inflammatory activity and belongs to the flavones.

Limonin is a limonoid, and a bitter, white, crystalline substance found in citrus and other plants. It is also known as limonoate D-ring-lactone and limonoic acid di-delta-lactone.

Crocin II is extracted from Crocus sativus L.

Procyanidin B1 is detected in human serum after intake of proanthocyanidin-rich grape seed extract.

Momordin Ic is a natural triterpenoid saponin enriched in various Chinese and Japanese natural medicines such as the fruit of Kochia scoparia (L.) Schrad.

Palmitic acid is a saturated fatty acid commonly found in both animals and plants.

Monoammoniumglycyrrhizinate is a constituent of the licorice root that has vital anti-viral activities that have been shown to inhibit the expression of 11_?HSD2 (11_?hydroxysteroid dehydrogenase type 2) via an indirect mechanism.

Procyanidin b2 inhibits human aortic smooth muscle cell proliferation and migration induced by advanced glycation end products.

Taxifolin is found to bind at the ATP-binding site on VEGFR-2 kinase with large value of binding energy and act as type I competitive inhibitor.

Cyanidin-3-O-glucoside chloride is a natural anthocyanin found in the fruits of some plants.

Typhaneoside is found in ginkgo nuts.

Tanshinones are the major bioactive compounds of Salvia miltiorrhiza Bunge (Danshen) roots, which are used in many therapeutic remedies in Chinese traditional medicine.