PLX-4720

Raf inhibitor

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Catalog No. A10002

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
PLX-4720 10mg A10002-10
$70.00
PLX-4720 25mg A10002-25
$100.00
PLX-4720 50mg A10002-50
$150.00
PLX-4720 100mg A10002-100
$240.00
PLX-4720 10mM * 1mL in DMSO A10002-10mM-D
$100.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.

PLX-4720

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Chemical Information

Catalog Num A10002
Actions Inhibitor
M. Wt 413.8
Formula C17H14ClF2N3O3S
Solubility DMSO>83mg/mL Water <1mg/mL Ethanol <1mg/mL
Purity >98%
Storage at -20°C 2 years
CAS No. 918505-84-7
Synonyms PLX4720
SMILES code CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Chemical Name N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide

Biological Activity

Description
PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.
Targets
Target Value
C-Raf-1(Y340D/Y341D)IC50: 6.7nM
B-Raf(V600E)IC50: 13nM
BRKIC50: 130nM
B-RafIC50: 160nM
FRKIC50: 1.3μM
CSKIC50: 1.5μM
SrcIC50: 1.7μM
FAKIC50: 1.7μM
FGFRIC50: 1.9μM
KDRIC50: 2.3μM
HGKIC50: 2.8μM
CSF-1RIC50: 3.3μM
AuroraAIC50: 3.4μM

Solubility

Solubility (25°C) * In vitro DMSO 83 mg/mL (200.56 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% CMC/0.5% Tween-80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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