PLX-4720

Catalog No.: A10002
Raf inhibitor
PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
Grouped product items
Product Name Price Stock Qty
PLX-4720 10mg
$50.00
In stock
PLX-4720 25mg
$80.00
In stock
PLX-4720 50mg
$120.00
In stock
PLX-4720 100mg
$200.00
In stock
PLX-4720 10mM * 1mL in DMSO
$100.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500

Important Notice: For research use only. We do not sell to patients.

Not your Region? View all Distributors

Adooq Products cited in reputable paper
Biological Activity
Discription PLX-4720 is a potent and selective inhibitor of B-RafV600E with IC50 of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-RafV600E than wild-type B-Raf.
Targets
Target Value
Product Information
Catalog Num A10002
Formula C17H14ClF2N3O3S
Molecular Weight 413.8
CAS Number 918505-84-7
SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)Cl)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 81 mg/mL (195.73 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+50% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.17 mL 120.83 mL 241.66 mL
0.5 mM 4.83 mL 24.17 mL 48.33 mL
1 mM 2.42 mL 12.08 mL 24.17 mL
5 mM 0.48 mL 2.42 mL 4.83 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2

  • Calculator Reset
Keywords: buy PLX-4720 | PLX-4720 Supplier | purchase PLX-4720 | PLX-4720 cost | PLX-4720 manufacturer | order PLX-4720 | PLX-4720 distributor | buy 918505-84-7 | 918505-84-7 Supplier | purchase 918505-84-7 | 918505-84-7 cost | 918505-84-7 manufacturer | order 918505-84-7 | 918505-84-7 distributor