PLX4032 (Vemurafenib)

Name: PLX4032 (Vemurafenib)
Brand: Adooq Bioscience
SKU: A10739
Rating: 5 (12 reviews)

Catalog No.: A10739

Raf inhibitor

Adooq's PLX4032 (Vemurafenib) has been cited by 12 publications

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.

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PLX4032 (Vemurafenib) 918504-65-1 Raf inhibitor

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Grouped product items
Size	Price	Stock
5mg	$35.00	In stock
10mg	$20.00	In stock
25mg	$45.00	In stock
50mg	$65.00	In stock
100mg	$95.00	In stock
1g	$500.00	In stock
200mg	$175.00	In stock
500mg	$300.00	In stock
*10mM 1mL in DMSO**	$45.00	In stock
Bulk Size	Bulk Discount

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Data Sheet SDS

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Adooq Products cited in reputable paper

Adooq's PLX4032 (Vemurafenib) has been cited by 12 publications

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138
Lee YJ, .et al. , Research Square, 2022, April 27th
Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
Guixin Zhu, .et al. , Nat Cell Biol, 2021, Sep;23(9):978-991 PMID: 34497368
Makoto Koyama, .et al. , Int J Oncol, 2020, Sep 2 PMID: 32901840
Kudo K, .et al. , FASEB J, 2018, Dec 3:fj201800664RR PMID: 30508500
Min Ho Choe, .et al. , Cell Death Dis, 2018, Jun; 9(6): 640 PMID: 29844307
Jan Dorrie, .et al. , Int J Mol Sci, 2018, Jan; 19(1): 289 PMID: 29346301
Aishwarya Kundu, .et al. , Mol Carcinog, 2017, Jan; 56(1): 49-61 PMID: 26878440
Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
Toshinori Sueda, .et al. , Sci Rep, 2016, 6: 18949 PMID: 26750638
Yanling Li, .et al. , Onco Targets Ther, 2015, 8: 1043-1051 PMID: 25999739

Biological Activity

Description

PLX4032 (Vemurafenib) also known as RG7204, Vemurafenib, R7204; RO5185426. PLX4032 is a B-raf inhibitor with an IC50 of 44 nM.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

Product Information

Catalog Num	A10739
Formula	C23H18ClF2N3O3S
Molecular Weight	489.9
CAS Number	918504-65-1
SMILES	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
Synonyms	RG7204,RO5185426,Zelboraf
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	83 mg/mL (169.41 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O (suspension)	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.41 mL	102.06 mL	204.12 mL
0.5 mM	4.08 mL	20.41 mL	40.82 mL
1 mM	2.04 mL	10.21 mL	20.41 mL
5 mM	0.41 mL	2.04 mL	4.08 mL

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