Prucalopride

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5-HT Receptor agonist

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Catalog No. A11771

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Prucalopride 5mg A11771-5

Regular Price: $40.00

Special Price: $32.00

Prucalopride 10mg A11771-10

Regular Price: $50.00

Special Price: $40.00

Prucalopride 25mg A11771-25

Regular Price: $90.00

Special Price: $72.00

Prucalopride 50mg A11771-50

Regular Price: $140.00

Special Price: $112.00

Prucalopride 10mM * 1mL in DMSO A11771-10mM-D

Regular Price: $50.00

Special Price: $40.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.

Prucalopride

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Chemical Information

Catalog Num A11771
Actions Agonist
M. Wt 367.9
Formula C18H26ClN3O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 179474-81-8
Synonyms Resolor
SMILES code COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl
Chemical Name 4-Amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide

Biological Activity

Description
Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.
Targets
Target Value
5-HT4Aki: 2.5nM
5-HT4Bki: 8nM
5-HT3ki: 3.822μM
5-HT1Aki: >10μM
5-HT1Bki: >10μM
5-HT1Dki: >10μM
5-HT1Eki: >10μM
5-HT1Fki: >10μM
5-HT2Aki: >10μM
5-HT2Bki: >10μM
5-HT2Cki: >10μM
5-HT5Aki: >10μM
5-HT6ki: >10μM
5-HT7ki: >10μM

Solubility

Solubility (25°C)* In vitro DMSO 60 mg/mL (163.1 mM)
Water <1 mg/mL (<1 mM)
Ethanol 38 mg/mL (103.29 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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