Purvalanol A

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CDK inhibitor

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Catalog No. A15517

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Purvalanol A 10mg A15517-10

Regular Price: $100.00

Special Price: $85.00

Purvalanol A 25mg A15517-25

Regular Price: $200.00

Special Price: $170.00

Purvalanol A 50mg A15517-50

Regular Price: $320.00

Special Price: $272.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.

Purvalanol A

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Chemical Information

Catalog Num A15517
Actions Inhibitor
M. Wt 388.89
Formula C19H25ClN6O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 212844-53-6
Synonyms NG-60
SMILES code CC(C)?N1C2=NC(N[[email protected]]?(C(C)?C)?CO)?=NC(NC3=CC(Cl)?=CC=C3)?=C2N=C1
Chemical Name 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine

Biological Activity

Description
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor. IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively.
Targets
Cdc2/CyclinB CDK2/CyclinE CDK2/CyclinA CDK4/CyclinD1
4 nM35 nM70 nM850 nM

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