Quarfloxin (CX-3543)

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rRNA biogenesis inhibitor

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Catalog No. A12380

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Quarfloxin (CX-3543) 5mg A12380-5
$250.00
Quarfloxin (CX-3543) 10mg A12380-10
$450.00
Quarfloxin (CX-3543) 25mg A12380-25
$900.00
Quarfloxin (CX-3543) 50mg A12380-50
$1,500.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Quarfloxin (CX-3543)

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Chemical Information

Catalog Num A12380
Actions Inhibitor
M. Wt 604.67
Formula C35H33FN6O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 865311-47-3
Synonyms CX 3543; Quarfloxacin; CX3543; CX-3543
SMILES code CN1CCC[[email protected]]1CCNC(=O)C2=CN3C4=CC5=CC=CC=C5C=C4OC6=C3C(=CC(=C6N7CCC(C7)C8=NC=CN=C8)F)C2=O
Chemical Name 5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide.

Biological Activity

Description
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

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