R406 (Tamatinib)

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Syk Inhibitor

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Catalog No. A10770

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
R406 (freebase) 10mg A10770-10
$150.00
R406 (freebase) 25mg A10770-25
$280.00
R406 (freebase) 50mg A10770-50
$500.00
R406 (freebase) 100mg A10770-100
$880.00
R406 (freebase) 10mM * 1mL in DMSO A10770-10mM-D
$130.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling.

R406 (Tamatinib)

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Chemical Information

Catalog Num A10770
Actions Inhibitor
M. Wt 470.5
Formula C22H23FN6O5
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 841290-80-0
Synonyms R-406
SMILES code CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C
Chemical Name N4-(2,2-dimethyl-3-oxo-4H-pyrid[1,4]oxazin-6-yl)-5-fluoro-N2-(3,4,5-trimethoxyphenyl)-2,4-pyrimidinediamine

Biological Activity

Description
R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling.
Targets
Syk (Cell-free assay)
41 nM

Solubility

Solubility (25°C) * In vitro DMSO 21 mg/mL (44.63 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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