R406 besylate

Name: R406 besylate
Brand: Adooq Bioscience
SKU: A10769
Rating: 100 (268 reviews)

Catalog No.: A10769

Syk Inhibitor

R406 besylate Chemical Structure

CAS NO. 841290-81-1

R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.

Availability: In stock

Package	Price	Qty
2 mg	Regular Price: $50.00 Special Price $40.00
5 mg	Regular Price: $100.00 Special Price $80.00
10 mg	Regular Price: $150.00 Special Price $120.00
50 mg	Regular Price: $500.00 Special Price $400.00
10mM * 1mL in DMSO	Regular Price: $373.00 Special Price $298.40
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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Biological Activity

R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.

Targets

Flt3 (Cell-free assay)	Syk (Cell-free assay)
N/A	41 nM

Solubility *

In vitro (25°C)	DMSO	92 mg/mL (146.34 mM)
	Water	Insoluble
	In vivo	5%dmso+95%cornoil	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.91 mL	79.54 mL	159.08 mL
0.5 mM	3.18 mL	15.91 mL	31.82 mL
1 mM	1.59 mL	7.95 mL	15.91 mL
5 mM	0.32 mL	1.59 mL	3.18 mL

*The above data is based on the productmolecular weight 628.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10769
Actions	Inhibitor
CAS No.	841290-81-1
Formula	C22H23FN6O5.C6H6O3S
M. Wt	628.6
Purity	>98%
Synonyms	R-406
SMILES	CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.