R406 besylate
R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
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Other Forms of R406 besylate
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Adooq Products cited in reputable paper
Adooq's R406 besylate has been cited by 2 publications
- Sina Ghasempour, .et al. , J Immunol, 2024, Oct 1;213(7):988-997 PMID: 39140892
- Gabriella Leung, .et al. , JCI insight, 2021, Dec 8;6(23):e149376 PMID: 34673575
Biological Activity
| Description | R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM. | ||
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Product Information
| Catalog Num | A10769 |
|---|---|
| Formula | C22H23FN6O5.C6H6O3S |
| Molecular Weight | 628.6 |
| CAS Number | 841290-81-1 |
| SMILES | CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C.C1=CC=C(C=C1)S(=O)(=O)O |
| Synonyms | R-406 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 92 mg/mL (146.34 mM) | |
| Water | Insoluble | ||
| In vivo | 5%dmso+95%cornoil | 5 mg/mL | |
| * <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. | |||
Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.91 mL | 79.54 mL | 159.08 mL |
| 0.5 mM | 3.18 mL | 15.91 mL | 31.82 mL |
| 1 mM | 1.59 mL | 7.95 mL | 15.91 mL |
| 5 mM | 0.32 mL | 1.59 mL | 3.18 mL |
Useful Calculator
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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)
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Calculate the dilution required to prepare a stock solution.This equation is commonly abbreviated as: C1V1 = C2V2
