Rilpivirine (R 278474, TMC 278)

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NNRT inhibitor

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Catalog No. A11542

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Rilpivirine 10mg A11542-10
$140.00
Rilpivirine 25mg A11542-25
$240.00
Rilpivirine 50mg A11542-50
$390.00
Rilpivirine 10mM * 1mL in DMSO A11542-10mM-D
$110.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.

Rilpivirine (R 278474, TMC 278)

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Chemical Information

Catalog Num A11542
Actions Inhibitor
M. Wt 366.4
Formula C22H18N6
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 500287-72-9
Synonyms R278474, TMC278, TMC-278
SMILES code CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N
Chemical Name 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile

Biological Activity

Description
Rilpivirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) with higher potency, longer half-life and reduced side-effect profile compared with older NNRTIs, such as efavirenz.

Solubility

Solubility (25°C)* In vitro DMSO 73 mg/mL (199.22 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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