Microbiology

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  1. Acetylcysteine is a pharmaceutical drug and nutritional supplement used primarily as a mucolytic agent and in the management of paracetamol (acetaminophen) overdose. Oral acetylcysteine is also used for the prevention of radiocontrast-induced nephropathy (a form of acute renal failure).

  2. ntRT inhibitor

    Adefovir dipivoxil is an orally-administered nucleotide analog reverse transcriptase inhibitor (ntRTI). It is used for treatment of hepatitis B and herpes simplex virus infection.
  3. Antifungal compound

    Amorolfine hydrochloride, is a morpholine antifungal reagent that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
  4. Amphotericin B is a polyene antifungal antibiotic from Streptomyces sp. Amphotericin B induces K+ leakage, which is separate from its lethal action, as was demonstrated in human erythrocytes and is due to the inhibitory effect on the Na+/K+ pump.
  5. HIV Protease inhibitor

    Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
  6. HIV Protease inhibitor

    Atazanavir is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV).
  7. Protein synthesis inhibitor

    Azomycin(2-Nitroimidazole) is an antimicrobial antibiotic produced by a strain of Nocardia mesenterica, which is active against aerobic Gram-positive and Gram-negative bacteria.
  8. Aztreonam is a synthetic monocyclic beta-lactam antibiotic (a monobactam), with the nucleus based on a simpler monobactam isolated from Chromobacterium violaceum.
  9. HIV-1 integrase inhibitor

    BMS-707035 is an HIV-1 integrase (IN) inhibitor. HIV-1 integrase (IN) represents a therapeutically advantageous viral target to treat HIV/AIDS in the clinic.

  10. HCV NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
  11. Cefditoren pivoxil is a third-generation cephalosporin antibiotic for oral use.
  12. Cefoselis is a widely used beta-lactam antibiotic.
  13. Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind.
  14. Dihydropyrimidinase Inhibitor

    Dihydromyricetin (Ampelopsin (flavanol); Ampeloptin) is a natural antioxidant with good prospects.
  15. PDGFR inhibitor

    Imatinib (Gleevec) is a number of tyrosine kinase enzymes specific inhibitor.
  16. HCV NS3/4A protease inhibitor

    Danoprevir is a potent inhibitor of the HCV NS3/4A serine protease.
  17. glucocorticoid receptor agonist

    Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs. It acts as an anti-inflammatory and immunosuppressant. Its potency is about 20-30 times that of the naturally occurring hormone hydrocortisone and 4-5 times of prednisone.
  18. Reverse transcriptase inhibitor

    Didanosine is a reverse transcriptase inhibitor, effective against HIV and used in combination with other antiretroviral drug therapy as part of highly active antiretroviral therapy (HAART).
  19. HIV integrase inhibitor

    Elvitegravir (GS-9137) is a potent inhibitor of the strand-transfer step of integration mediated by human immunodeficiency virus type 1 (HIV-1) integrase.
  20. Emodin is a purgative resin, from rhubarb, the buckthorn and Japanese Knotweed (Fallopia japonica). It belongs to a family of compounds called anthraquinones, which have shown anti-inflammatory and anticancer effects

  21. NRT inhibitor

    Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection.
  22. Antiviral agent

    Famciclovir(BRL 42810) is a guanine analogue antiviral drug used for the treatment of various herpesvirus infections.
  23. Bcr-Abl inhibitor

    Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
  24. Isoconazole nitrate (Travogen) is an azole antifungal reagent.
  25. NLRP3 inflammasome inhibitor

    Isoliquiritigenin is a licorice chalconoid, a type of natural phenols that is currently under experimentation phase testing for use as a cancer treatment as well as an aide for cocaine addiction.
  26. Kanamycin sulfate is an aminoglycoside bacteriocidal antibiotic.
  27. Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).
  28. anthelmintic and immunomodulator

    Levamisole hydrochloride is an anthelmintic and immunomodulator belonging to a class of synthetic imidazothiazole derivatives.
  29. Levofloxacin is a fluoroquinolone antibiotic. It is active against S. aureus, S. epidermidis, B. subtilis, E. coli, P. aeruginosa, and K. pneumoniae (MICs = 0.25, 0.25, 0.5, 0.03, 4, and 0.25 μg/ml, respectively).
  30. Protein synthesis inhibitor

    Linezolid is a synthetic antibiotic used for the treatment of serious infections.
  31. HIV Protease inhibitor

    Lopinavir is an inhibitor of the HIV protease.
  32. CCR antagonist

    Maraviroc is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection.
  33. synthetic glucocorticoid receptor agonist

    Methylprednisolone is an apoptosis inducer and was also found to inhibit human small cell lung cancer cell growth in vitro.
  34. nitroimidazole antibiotic medication

    Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.
  35. Nevirapine (Viramune) is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase.
  36. Polymyxin B Sulfate is a cationic surfactant antibiotic agent. A mixture of polymyxins B1 and B2, increases the permeability of the cell membrane.
  37. Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain.
  38. Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).
  39. HIV-1 integrase inhibitor

    Raltegravir (MK-0518) targets integrase, an HIV enzyme that integrates the viral genetic material into human chromosomes, a critical step in the pathogenesis of HIV.
  40. ICN1229, ICN-1229, ICN 1229

    Ribavirin (ICN-1229) is an antiviral agent against a broad spectrum of viruses including HCV, HIVl, and RSV.
  41. RNA polymerase inhibitor

    Antibiotic; inhibits bacterial RNA polymerase. Prototypical activator of the pregnane X receptor (PXR).
  42. HIV Protease inhibitor

    Ritonavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease.Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles.
  43. HCV NS3-4A protease inhibitor

    Telaprevir (VX-950) is known as protease inhibitors that inhibits the hepatitis C virus NS3.4A serine protease.
  44. HIV reverse transcriptase inhibitor

    Tenofovir is in a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs). It works by decreasing the amount of HIV in the blood.
  45. nucleotide reverse transcriptase inhibitor

    Tenofovir Disoproxil Fumarate is employed as an anti-HIV agend and a reverse transcriptase inhibitor.
  46. Tigecycline is bacteriostatic and is a protein synthesis inhibitor by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation.
  47. Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy, which disrupts both gram positive and gram negative bacteria by interfering with cell wall and peptidoglycan synthesis.
  48. CCR5 antagonist

    Vicriviroc Malate is a second generation orally active CCR5 antagonist, which is also a potent inhibitor of HIV-1 entry into target cells, with a mean IC50 =0.46 nM and IC50 =1~10 nM to HIV isolates (n=52).
  49. HCV Protease inhibitor

    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
  50. nucleoside analogue reverse transcriptase inhibitor

    Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection.

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