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Ro 31-8220

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PKC inhibitor

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Catalog No. A13514

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Ro 31-8220 10mg A13514-10

Regular Price: $120.00

Special Price: $108.00

Ro 31-8220 25mg A13514-25

Regular Price: $250.00

Special Price: $225.00

Ro 31-8220 50mg A13514-50

Regular Price: $420.00

Special Price: $378.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.

Ro 31-8220

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Chemical Information

Catalog Num A13514
Actions Inhibitor
M. Wt 553.7
Formula C25H23N5O2SCH3SO3H
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 138489-18-6
Synonyms BIM IX, Bisindolylmaleimide IX (mesylate)
SMILES code CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
Chemical Name 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester-methanesulfonate, carbamimidothioic acid

Biological Activity

Description
Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate (PMA, IC50 = 1.35 x 10(-6) M) or diacylglycerols (OAG, diC8) by 95%.
Targets
PKCα PKCβ2 PKCβ1 PKCε PKCγ
5 nM14 nM24 nM24 nM27 nM

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