Roflumilast

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PDE inhibitor

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Catalog No. A10804

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Roflumilast 5mg A10804-5

Regular Price: $55.00

Special Price: $44.00

Roflumilast 10mg A10804-10

Regular Price: $90.00

Special Price: $72.00

Roflumilast 50mg A10804-50

Regular Price: $180.00

Special Price: $144.00

Roflumilast 100mg A10804-100

Regular Price: $320.00

Special Price: $256.00

Roflumilast 10mM * 1mL in DMSO A10804-10mM-D

Regular Price: $103.00

Special Price: $82.40

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.

Roflumilast

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Chemical Information

Catalog Num A10804
Actions Inhibitor
M. Wt 403.2
Formula C17H14Cl2F2N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 162401-32-3
Synonyms Daxas, Daliresp
SMILES code C1CC1COC2=C(C=CC(=C2)C(=O)NC3=C(C=NC=C3Cl)Cl)OC(F)F
Chemical Name 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide

Biological Activity

Description
Roflumilast acts as a selective, long-acting inhibitor of the enzyme PDE-4.
Targets
Target Value
PDE4B2IC50: 0.2nM
PDE4A1IC50: 0.7nM
PDE4B1IC50: 0.7nM
PDE4A4IC50: 0.9nM
PDE4C1IC50: 3nM
PDE4C2IC50: 4.3nM

Solubility

Solubility (25°C) * In vitro DMSO 81 mg/mL (200.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 15 mg/mL (37.2 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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