S3I-201 (NSC 74859)

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Stat3 Inhibitor

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Catalog No. A10817

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
S3I-201 5mg A10817-5

Regular Price: $40.00

Special Price: $32.00

S3I-201 10mg A10817-10

Regular Price: $70.00

Special Price: $56.00

S3I-201 50mg A10817-50

Regular Price: $175.00

Special Price: $140.00

S3I-201 100mg A10817-100

Regular Price: $330.00

Special Price: $264.00

S3I-201 (NSC 74859) 10mM * 1mL in DMSO A10817-10mM-D

Regular Price: $60.00

Special Price: $48.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.

S3I-201 (NSC 74859)

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Chemical Information

Catalog Num A10817
Actions Inhibitor
M. Wt 365.4
Formula C16H15NO7S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 501919-59-1
Synonyms S3I201, NSC74859 , NSC-74859
SMILES code CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
Chemical Name 2-hydroxy-4-(2-(tosyloxy)acetamido)benzoic acid

Biological Activity

Description
S3I-201 (NSC 74859) is a novel inhibitor of Stat3 that inhibits Stat3, Stat3 complex formation and Stat3-DNA binding activity in vitro (IC50 = 86 ± 33 µM) and Stat3-dependent transcriptional activities.
Targets
STAT3 (Cell-free assay)
86 μM

Solubility

Solubility (25°C) * In vitro DMSO 73 mg/mL (199.8 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 5% DMSO, 95% PEG 300 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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