SB-408124

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OX Receptor Antagonist

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Catalog No. A11567

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SB-408124 10mg A11567-10
$80.00
SB-408124 25mg A11567-25
$160.00
SB-408124 50mg A11567-50
$280.00
SB-408124 100mg A11567-100
$500.00
SB-408124 10mM * 1mL in DMSO A11567-10mM-D
$88.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.

SB-408124

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Chemical Information

Catalog Num A11567
Actions Antagonist
M. Wt 356.37
Formula C19H18F2N4O
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 288150-92-5
Synonyms SB408124, SB 408124
SMILES code CC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F
Chemical Name N-(6,8-Difluoro-2-methyl-4-quinolin?yl)-N'-[4-(dimethylamino)phenyl]urea

Biological Activity

Description
SB-408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo.
Targets
OX1 (membrane) OX1 (whole cell)
27 nM(Ki)57 nM(Ki)

Solubility

Solubility (25°C) * In vitro DMSO 36 mg/mL (101.01 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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