Smoothened



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Catalog No. Product Name Application Product Information
A13204

BMS-833923 (XL-139)

Smoothened inhibitor
BMS-833923 (or XL-139) is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity.
A12774

LDE225 Diphosphate

Smoothened Inhibitor
LDE225 is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity.
A13881

PF-04449913

Smoothened inhibitor
PF-04449913 is a potent and orally bioavailable inhibitor of smoothened.
A12775

PF-5274857

Smoothened Inhibitor
PF-5274857 is a novel Smo antagonist that specifically binds to Smo with a K(i) of 4.6 ± 1.1 nmol/L and completely blocks the transcriptional activity of the downstream gene Gli1 with an IC(50) of 2.7 ± 1.4 nmol/L in cells.
A11480

Purmorphamine

Hedgehog signaling activator
Purmorphamine is a 2,6,9-trisubstituted purine that promotes the differentiation of both human and mouse mesenchymal progenitor cells into osteoblasts.

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