SNS-032 (BMS-387032)

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CDK inhibitor

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Catalog No. A10850

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SNS-032 5mg A10850-5

Regular Price: $40.00

Special Price: $34.00

SNS-032 10mg A10850-10

Regular Price: $60.00

Special Price: $51.00

SNS-032 50mg A10850-50

Regular Price: $180.00

Special Price: $153.00

SNS-032 100mg A10850-100

Regular Price: $300.00

Special Price: $255.00

SNS-032 (BMS-387032) 10mM * 1mL in DMSO A10850-10mM-D

Regular Price: $89.00

Special Price: $75.65

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.

SNS-032 (BMS-387032)

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Chemical Information

Catalog Num A10850
Actions Inhibitor
M. Wt 380.5
Formula C17H24N4O2S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 345627-80-7
Synonyms SNS032, BMS-387032, BMS387032
SMILES code CC(C)(C)C1=CN=C(O1)CSC2=CN=C(S2)NC(=O)C3CCNCC3
Chemical Name N-[5-[[[5-(1,1-Dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide

Biological Activity

Description
SNS-032 (BMS-387032) is a highly selective and potent inhibitor of cyclin-dependent kinases (Cdks) 2, 7, and 9, with in vitro growth inhibitory effects and ability to induce apoptosis in malignant B cells.
Targets
Target Value
CDK9/CyclinTIC50: 4nM
CDK2/CyclinAIC50: 38nM
CDK2/CyclinEIC50: 48nM
CDK7/CyclinHIC50: 62nM
GSK-3αIC50: 230nM
CDK5/p35IC50: 340nM
CDK1/CyclinBIC50: 480nM
GSK-3βIC50: 660nM
CDK4/CyclinDIC50: 925nM
CDK6/CyclinDIC50: >1μM

Solubility

Solubility (25°C) * In vitro DMSO 76 mg/mL (199.72 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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