SNX-2112

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Hsp90 inhibitor

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Catalog No. A11189

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SNX-2112 5mg A11189-5

Regular Price: $150.00

Special Price: $127.50

SNX-2112 10mg A11189-10

Regular Price: $220.00

Special Price: $187.00

SNX-2112 50mg A11189-50

Regular Price: $550.00

Special Price: $467.50

SNX-2112 100mg A11189-100

Regular Price: $920.00

Special Price: $782.00

SNX-2112 10mM * 1mL in DMSO A11189-10mM-D

Regular Price: $198.00

Special Price: $168.30

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

SNX-2112

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Chemical Information

Catalog Num A11189
Actions Inhibitor
M. Wt 464.48
Formula C23H27F3N4O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 908112-43-6
Synonyms SNX2112, PF 04928473
SMILES code CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)O)C(F)(F)F)C
Chemical Name 2-[(trans-4-Hydroxycyclohexyl)amino]-4-[4,5,6,7-tetrahydro-6,6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]benzamide

Biological Activity

Description

SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent

Targets
HSP90α HSP90β
30 nM(Ka)30 nM(Ka)

Solubility

Solubility (25°C) * In vitro DMSO 93 mg/mL (200.22 mM)
Water <1 mg/mL (<1 mM)
Ethanol 1 mg/mL (2.15 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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