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|Storage||at -20°C 2 years|
|Synonyms||SNX2112, PF 04928473|
SNX-2112 is a heat shock protein 90 (Hsp90) inhibitor with anticancer properties currently in clinical trials. SNX-2112 induced autophagy in a time- and dose-dependent manner via Akt/mTOR/p70S6K inhibition. SNX-2112 induces significant apoptosis and autophagy in human melanoma A-375 cells, and may be an effective targeted therapy agent
|Solubility (25°C) *||In vitro||DMSO||93 mg/mL (200.22 mM)|
|Water||<1 mg/mL (<1 mM)|
|Ethanol||1 mg/mL (2.15 mM)|
|In vivo||0.5% CMC/0.25% Tween 80||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
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