Spliceostatin A

Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Adooq's Spliceostatin A has been cited by 8 publications
  • Arfaoui A, .et al. , EMBO Mol Med, 2019, Oct;11(10):e9930 PMID: 31476112
  • KE Mengwasser, .et al. , ‎Mol Cell, 2019, S1097-2765(18)31062-1 PMID: 30686591
  • Sahar AlShareef, .et al. , BMC Genomics, 2017, 18: 260 PMID: 28347276
  • Ling Y, .et al. , Plant J, 2017, Jan;89(2):291-309 PMID: 27664942
  • Matthew J. Hangauer, .et al. , Nature, 2017, Nov 9; 551(7679): 247-250 PMID: 29088702
  • Ji Hyun Kim, .et al. , Animal Cells and Systems, 2017, 21:1, 17-22 PMID: 30460047
  • M Tanikawa, .et al. , Oncogenesis, 2016, Dec; 5(12): e280 PMID: 27991914
  • Ji Hyun Kim, .et al. , Biochim Biophys Acta, 2016, Jun; 1863(6 Pt A): 1307-1318 PMID: 27033521
Biological Activity
DescriptionSpliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.
Cell Research
Cell LineTypeValueDescriptionReferences
Product Information
Catalog NumA12700
FormulaC28H43NO8
Molecular Weight521.65
CAS Number391611-36-2
SMILESC[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@@](O2)(C)OC)CO3)O)C)NC(=O)/C=C/[C@H](C)OC(=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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