T0070907

Catalog No.: A11588
PPAR-γ antagonist
T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
Grouped product items
Product Name Price Stock Qty
T0070907 5mg
$40.00
In stock
T0070907 10mg
$60.00
In stock
T0070907 50mg
$160.00
In stock
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Biological Activity
Discription T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
Targets
Target Value
Product Information
Catalog Num A11588
Formula C12H8ClN3O3
Molecular Weight 277.66
CAS Number 313516-66-4
SMILES ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O
Synonyms T 0070907
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO 24 mg/mL (86.43 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+45% PEG 300+ddH2O 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 36.02 mL 180.08 mL 360.15 mL
0.5 mM 7.2 mL 36.02 mL 72.03 mL
1 mM 3.6 mL 18.01 mL 36.02 mL
5 mM 0.72 mL 3.6 mL 7.2 mL
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