Target & Activity
| Target | Activity | Value |
|---|---|---|
| PPARγ (Cell-free assay) | 1 nM | |
| PPARα (Cell-free assay) | 0.85 μM | |
| PPARδ (Cell-free assay) | 1.8 μM |
Fig. 1 · Structure
Documents & Downloads
T0070907
Cat. No.
A11588
CAS
313516-66-4
PPAR-γ antagonist
T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 313516-66-4 |
| Applications | PPAR-γ antagonist |
| Formula | C12H8ClN3O3 |
| Molecular Weight | 277.66 |
| SMILES | ClC1=CC=C([N+]([O-])=O)C=C1C(NC2=CC=NC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 24 mg/mL (86.43 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
In Vivo Preparation
- Concentration
- 8 mg/mL
- Vehicle
- 5% DMSO+45% PEG 300+ddH2O
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.