T0070907 ON SALE PPAR-γ antagonist

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Catalog No. A11588

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
T0070907 5mg A11588-5

Regular Price: $40.00

Special Price: $34.00

T0070907 10mg A11588-10

Regular Price: $60.00

Special Price: $51.00

T0070907 50mg A11588-50

Regular Price: $200.00

Special Price: $170.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.

T0070907

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Chemical Information

Catalog Num A11588
Actions Antagonist
M. Wt 277.66
Formula C12H8ClN3O3
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 313516-66-4
Synonyms T 0070907
SMILES code N/A
Chemical Name 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide

Biological Activity

Description
T0070907 was identified as a potent and selective PPARgamma antagonist. With an apparent binding affinity (concentration at 50% inhibition of [(3)H]rosiglitazone binding or IC(50)) of 1 nm, T0070907 covalently modifies PPARgamma on cysteine 313 in helix 3 of human PPARgamma2.
Targets
PPARγ (Cell-free assay) PPARα (Cell-free assay) PPARδ (Cell-free assay)
1 nM0.85 μM1.8 μM

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