TAE684

Catalog No.: A10662
ALK Inhibitor
TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).
Grouped product items
Product Name Price Stock Qty
TAE684 5mg
$80.00
In stock
TAE684 10mg
$120.00
In stock
TAE684 50mg
$320.00
In stock
TAE684 100mg
$450.00
In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Adooq's TAE684 has been cited by 3 publications
  • Yue Guo, .et al. , Cell Biosci, 2022, Dec 30;12(1):210 PMID: 36585695
  • Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961
  • Li T, .et al. , Oncogene, 2018, Nov;37(47):6180-6194 PMID: 30013190
  • Biological Activity
    Discription TAE684 is a inhibitor of ALK and also a potent inhibitor of LRRK2 kinase activity (IC(50) of 7.8nM against wild-type LRRK2, 6.1nM against the G2019S mutant).
    Targets
    Target Value
    Product Information
    Catalog Num A10662
    Formula C30H40ClN7O3S
    Molecular Weight 614.2
    CAS Number 761439-42-3
    SMILES CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC
    Synonyms NVP-TAE684
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 3 mg/mL (4.88 mM)
    Water Insoluble
    Ethanol Insoluble
    In vivo 30% PEG400+0.5% Tween80+5% propylene glycol, pH 4 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 16.28 mL 81.41 mL 162.81 mL
    0.5 mM 3.26 mL 16.28 mL 32.56 mL
    1 mM 1.63 mL 8.14 mL 16.28 mL
    5 mM 0.33 mL 1.63 mL 3.26 mL
    Useful Calculator

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    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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