TAK-285

Catalog No.: A11236
HER2/EGFR inhibitor
TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB). TAK-285 has inhibitory activity against HER2 and EGFR kinases with IC50 values for HER2 and EGFR of 17 nmol/L (95% CI 12-24) and 23 nmol/L (95% CI 18-30), respectively.[1]
Grouped product items
Product Name Price Stock Qty
TAK-285 5mg
$81.00
In stock
TAK-285 10mg
$138.00
In stock
TAK-285 25mg
$243.00
In stock
TAK-285 50mg
$405.00
In stock
TAK-285 10mM * 1mL in DMSO
$256.00
In stock
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Biological Activity
Discription TAK-285 is an investigational HER2/EGFR inhibitor that penetrates the CNS in Rats with an Intact Blood Brain Barrier (BBB). TAK-285 has inhibitory activity against HER2 and EGFR kinases with IC50 values for HER2 and EGFR of 17 nmol/L (95% CI 12-24) and 23 nmol/L (95% CI 18-30), respectively.[1]
Targets
Target Value
Product Information
Catalog Num A11236
Formula C26H25ClF3N5O3
Molecular Weight 548
CAS Number 871026-44-7
SMILES CC(C)(CC(=O)NCCN1C=CC2=C1C(=NC=N2)NC3=CC(=C(C=C3)OC4=CC=CC(=C4)C(F)(F)F)Cl)O
Synonyms TAK285
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 97 mg/mL (177.02 mM)
Water Insoluble
Ethanol 48 mg/mL (87.59 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.25 mL 91.24 mL 182.48 mL
0.5 mM 3.65 mL 18.25 mL 36.5 mL
1 mM 1.82 mL 9.12 mL 18.25 mL
5 mM 0.36 mL 1.82 mL 3.65 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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