TAK-632

pan-RAF inhibitor

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Catalog No. A13323

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
TAK-632 5mg A13323-5
$65.00
TAK-632 10mg A13323-10
$100.00
TAK-632 25mg A13323-25
$200.00
TAK-632 50mg A13323-50
$300.00
TAK-632 10mM * 1mL in DMSO A13323-10mM-D
$80.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

TAK-632 is a potent pan-RAF inhibitor with favorable in
vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.

TAK-632

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Chemical Information

Catalog Num A13323
Actions Inhibitor
M. Wt 554.51
Formula C27H18F4N4O3S
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 1228591-30-7
Synonyms TAK 632; TAK632
SMILES code C1CC1C(=O)NC2=NC3=C(S2)C(=C(C=C3)OC4=CC(=C(C=C4)F)NC(=O)CC5=CC(=CC=C5)C(F)(F)F)C#N
Chemical Name N-(7-cyano-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclopropanecarboxamide

Biological Activity

Description
TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50, 2.4 nM; BRAF(wt), 8.3 nM; CRAF, 1.4 nM; pMEK (A375) IC50, 12 nM; pMEK (HMVII), 49 nM; V/B ratio.
Targets
Target Value
C-RafIC50: 1.4nM
B-RafIC50: 8.3nM
AuroraBIC50: 66nM
PDGFRβIC50: 120nM
FGFR3IC50: 280nM
GSK-3βIC50: 500nM
CDK2IC50: 580nM
p38αIC50: 600nM
PDGFRαIC50: 610nM
Tie-2IC50: 740nM
CDK1IC50: 790nM
Chk1IC50: 1.4μM
MEK1IC50: 3.7μM
IKKβIC50: 3.7μM
PKAIC50: >10μM
PKCθIC50: >10μM
CK1δIC50: >10μM
ERK1IC50: >10μM
EGFRIC50: >10μM
HER2IC50: >10μM
JNK1IC50: >10μM
c-MetIC50: >10μM
c-KitIC50: >10μM
SrcIC50: >10μM
IRIC50: >10μM
MEKK1IC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 100 mg/mL (180.33 mM)
Water <1 mg/mL (<1 mM)
Ethanol 2 mg/mL (3.6 mM)
In vivo 2% DMSO/98% PEG 300 5 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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