Torin 1

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mTOR inhibitor

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Catalog No. A11587

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Torin 1 10mg A11587-10

Regular Price: $90.00

Special Price: $72.00

Torin 1 25mg A11587-25

Regular Price: $180.00

Special Price: $144.00

Torin 1 50mg A11587-50

Regular Price: $300.00

Special Price: $240.00

Torin 1 100mg A11587-100

Regular Price: $520.00

Special Price: $416.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.

Torin 1

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Chemical Information

Catalog Num A11587
Actions Inhibitor
M. Wt 607.62
Formula C35H28F3N5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1222998-36-8
Synonyms Torin1
SMILES code CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
Chemical Name 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one

Biological Activity

Description
Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
Targets
Target Value
mTORC1IC50: 2nM
mTORIC50: 4.32nM
DNA-PKIC50: 6.34nM
mTORC2IC50: 10nM
p110γIC50: 171nM
C2αIC50: 176nM
p110α/p85αIC50: 250nM
hVPS34IC50: 533nM
C2βIC50: 549nM
p110δ/p85αIC50: 564nM
PI4KβIC50: 6680nM
PI4KαIC50: >10μM

Solubility

Solubility (25°C) * In vitro DMSO 2 mg/mL (3.29 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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