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mTOR Inhibitor

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Catalog No. A11187

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
WYE-687 5mg A11187-5

Regular Price: $80.00

Special Price: $64.00

WYE-687 10mg A11187-10

Regular Price: $140.00

Special Price: $112.00

WYE-687 50mg A11187-50

Regular Price: $380.00

Special Price: $304.00

WYE-687 100mg A11187-100

Regular Price: $680.00

Special Price: $544.00

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin(mTOR).


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Chemical Information

Catalog Num A11187
Actions Inhibitor
M. Wt 528.61
Formula C28H32N8O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1062161-90-3
Synonyms WYE687
Chemical Name N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamic acid methyl ester

Biological Activity


WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin(mTOR).

Target Value
mTORIC50: 7nM
PI3KαIC50: 0.81μM
PI3KγIC50: 3.11μM
p38αIC50: 28.9μM
SrcIC50: >50μM
VEGFR2IC50: >50μM
Abl1IC50: >50μM
AuroraBIC50: >50μM
CDK1/CyclinBIC50: >50μM
CDK2/CyclinAIC50: >50μM
Chk1IC50: >50μM
ERK2IC50: >50μM
FynIC50: >50μM
GCKIC50: >50μM
HckIC50: >50μM
IKKαIC50: >50μM
LynIC50: >50μM
MetIC50: >50μM
MK2IC50: >50μM
PDGFRαIC50: >50μM
PKAIC50: >50μM
PKBαIC50: >50μM
PKCαIC50: >50μM
PKCβIC50: >50μM
ROCK1IC50: >50μM
RSK1IC50: >50μM


Solubility (25°C)* In vitro DMSO 0.5 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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