ZCL-278

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Cdc42 GTPase inhibitor

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Catalog No. A13403

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ZCL-278 10mg A13403-10

Regular Price: $60.00

Special Price: $51.00

ZCL-278 25mg A13403-25

Regular Price: $120.00

Special Price: $102.00

ZCL-278 50mg A13403-50

Regular Price: $200.00

Special Price: $170.00

ZCL-278 100mg A13403-100

Regular Price: $350.00

Special Price: $297.50

ZCL-278 10mM * 1mL in DMSO A13403-10mM-D

Regular Price: $75.00

Special Price: $63.75

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.

ZCL-278

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Chemical Information

Catalog Num A13403
Actions Inhibitor
M. Wt 584.89
Formula C21H19BrClN5O4S2
Solubility DMSO
Purity >98%
Storage at -20°C 2 years
CAS No. 587841-73-4
Synonyms ZCL278, ZCL 278
SMILES code CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C
Chemical Name 2-(4-Bromo-2-chlorophenoxy)-N-[[[4-?[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]pheny?l]amino]thioxomethyl]acetamide

Biological Activity

Description
ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Targets
Cdc42 GTPase
11.4 μM(Kd)

Solubility

Solubility (25°C)* In vitro DMSO 100 mg/mL (170.97 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

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