ZCL-278

Catalog No.: A13403
Cdc42 GTPase inhibitor
ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Grouped product items
Product Name Price Stock Qty
ZCL-278 10mg
$60.00
In stock
ZCL-278 25mg
$120.00
In stock
ZCL-278 50mg
$200.00
In stock
ZCL-278 100mg
$350.00
In stock
ZCL-278 10mM * 1mL in DMSO
$75.00
In stock
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Biological Activity
Discription ZCL-278 is a selective inhibitor of Cdc42. Targets the binding site of the Cdc42 guanine nucleotide exchange factor, intersectin (ITSN). Inhibits Cdc42-mediated cellular effects, including microspike formation in 3T3 fibroblasts and neuronal branching in primary neonatal cortical neurons. Also suppresses cell motility and migration in PC3 cells, without cytotoxic effects.
Targets
Target Value
Product Information
Catalog Num A13403
Formula C21H19BrClN5O4S2
Molecular Weight 584.89
CAS Number 587841-73-4
SMILES CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)NC(=S)NC(=O)COC3=C(C=C(C=C3)Br)Cl)C
Synonyms ZCL278, ZCL 278
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 99 mg/mL (169.26 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.1 mL 85.49 mL 170.97 mL
0.5 mM 3.42 mL 17.1 mL 34.19 mL
1 mM 1.71 mL 8.55 mL 17.1 mL
5 mM 0.34 mL 1.71 mL 3.42 mL
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