5,3',4',3'',4'',5''-6-O-Ethyl-EGCG

Catalog No.: A75595
HIF-1α/CBR1 Inhibitor
5,3',4',3'',4'',5''-6-O-Ethyl-EGCG is a selective inhibitor of HIF-1α and CBR1. This compound effectively reduces the expression levels of HIF-1α and CBR1 at both mRNA and protein levels, making it a valuable tool for investigating hypoxia-related pathways and metabolic regulation. Its optimized structure enhances its potency as an adjuvant in various chemical research applications focused on cellular response to hypoxia.
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5mg
10mg
50mg
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description5,3',4',3'',4'',5''-6-O-Ethyl-EGCG is a selective inhibitor of HIF-1α and CBR1. This compound effectively reduces the expression levels of HIF-1α and CBR1 at both mRNA and protein levels, making it a valuable tool for investigating hypoxia-related pathways and metabolic regulation. Its optimized structure enhances its potency as an adjuvant in various chemical research applications focused on cellular response to hypoxia.
Product Information
Catalog NumA75595
FormulaC34H42O11
Molecular Weight626.69
CAS Number1613308-63-6
SMILESO=C(C1=CC(OCC)=C(C(OCC)=C1)OCC)O[C@H]2[C@@H](C3=CC(OCC)=C(C(O)=C3)OCC)OC4=CC(O)=CC(OCC)=C4C2
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