7-Hydroxyneolamellarin A is a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α), a key regulator of cellular responses to low oxygen levels. Derived from the sponge Dendrilla nigra, this natural product effectively reduces HIF-1α protein accumulation and suppresses its transcriptional activity on vascular endothelial growth factor (VEGF). Research applications of 7-Hydroxyneolamellarin A include investigations into cancer biology and the modulation of tumor microenvironments.
7-Hydroxyneolamellarin A is a potent inhibitor of hypoxia-inducible factor-1α (HIF-1α), a key regulator of cellular responses to low oxygen levels. Derived from the sponge Dendrilla nigra, this natural product effectively reduces HIF-1α protein accumulation and suppresses its transcriptional activity on vascular endothelial growth factor (VEGF). Research applications of 7-Hydroxyneolamellarin A include investigations into cancer biology and the modulation of tumor microenvironments.
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