Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Betaxolol-d7 hydrochloride is a deuterium-labeled analog of Betaxolol hydrochloride, functioning primarily as a selective beta-1 adrenergic receptor blocker. This stable isotope is instrumental in pharmacokinetic studies and metabolic investigations, particularly in the context of hypertension and glaucoma research. Its unique labeling enables precise tracking and quantification in various biological assays, facilitating advanced research into cardiovascular and ocular conditions. -
Stable Isotope
Ractopamine-d6 is a deuterium-labeled analogue of Ractopamine, a potent β-adrenergic receptor (βAR) agonist with a Kd of approximately 25 nM for both pig β1AR and β2AR. This stable isotope enables detailed studies of protein metabolism and is instrumental in research focused on enhancing lean tissue growth and improving production efficiency in swine. Its application is crucial for understanding the biochemical pathways influenced by β-adrenergic signaling in agricultural and animal health settings. -
Adrenergic Receptor Inhibitor
Bamosiran is a small interfering RNA that specifically targets the β-adrenergic receptor 2. This compound is recognized for its ability to significantly reduce intraocular pressure, making it valuable in the study of ocular conditions. Its role as an adrenergic receptor inhibitor aids in investigating therapeutic strategies for glaucoma and other eye disorders. -
β2-adrenergic Receptor Agonist
β2AR agonist 3 is a selective agonist of the β2-adrenergic receptor, involved in mediating various physiological responses. This compound has demonstrated potential in the modulation of metabolic pathways and holds promise for research in type 2 diabetes. Its application may facilitate investigations into β2AR-related mechanisms and therapeutic approaches in metabolic disorders. -
α1 Adrenergic Receptors Antagonist
Doxazosin-d8 is a deuterium-labeled derivative of Doxazosin, a selective antagonist of postsynaptic α1 adrenergic receptors. This compound exhibits potent inhibitory effects on α1 receptor-mediated pathways, making it valuable for studying cardiovascular function and related pharmacological effects. Doxazosin-d8 can be utilized in research applications focusing on hypertension, benign prostatic hyperplasia, and other conditions influenced by α1 adrenergic signaling. -
Alpha 2-adrenergic Receptor Antagonist
Vatinoxan is an alpha 2-adrenergic receptor antagonist that selectively inhibits α2-adrenergic receptors, primarily affecting the peripheral nervous system due to limited central nervous system penetration. By binding to these receptors, Vatinoxan mitigates cardiovascular responses typically induced by α2-adrenergic agonists. This compound is valuable in research related to cardiovascular physiology, sedation, and analgesia. -
β-Adrenergic Receptor Blocker
Proxodolol free base is a selective β-adrenergic receptor blocker. It exhibits efficacy in reducing blood pressure and may be utilized in research focused on arterial hypertension and related cardiovascular conditions. This compound can aid in elucidating the mechanisms of β-adrenergic signaling and its impact on cardiovascular health. -
Stable Isotope
Guanfacine-13C,15N3 is a stable isotope-labeled form of Guanfacine, an orally active noradrenergic α2A adrenergic receptor agonist. This compound exhibits high selectivity for the α2A receptor subtype, contributing to its pharmacological effects such as hypotension and sedation. Guanfacine-13C,15N3 serves as a valuable tool in research applications focused on prefrontal cortex cognitive disorders, including Tourette's syndrome and attention deficit hyperactivity disorder (ADHD). -
Drug Derivative
Photoazolol-1 is a β-adrenergic receptor (βAR) blocker derivative that exhibits unique light-dependent activity. Upon photoactivation, Photoazolol-1 transitions from an inverse agonist to a neutral antagonist, making it a valuable tool for studies involving receptor modulation. This compound's distinct photochemical properties enable innovative research applications in drug development and receptor behavior analysis. -
α1-AR Antagonist
RS-100329 is a selective antagonist of the α1-adrenergic receptor (α1-AR), demonstrating effective inhibition of α1-AR-mediated contractions in lower urinary tract tissues both in vitro and in vivo. This compound is valuable for research applications related to the symptomatic management of benign prostatic hyperplasia, facilitating studies on urinary tract dynamics and receptor signaling pathways. -
β3-Adrenergic Receptor Agonist
Fasobegron is a potent β3-adrenergic receptor agonist, exhibiting a human EC50 of 4.8 nM. Additionally, it demonstrates an EC50 of 250 nM for human β1-adrenergic receptors. This compound is primarily utilized in research related to the treatment of overactive bladder. -
β2AR Blocker
Todralazine is a β2 adrenergic receptor (β2AR) blocker that exhibits antioxidant properties and free radical scavenging activity. This compound demonstrates potential in the regulation of blood pressure through its anti-hypertensive effects. It is a valuable reagent for research applications focused on cardiovascular physiology and the modulation of adrenergic signaling pathways. -
Inotropic Compound
Butopamine hydrochloride is an orally active inotropic compound that primarily targets beta-adrenergic receptors. It is known to enhance cardiac output by increasing heart rate and contractility, making it a valuable tool in cardiovascular research. Its potency may surpass that of Dobutamine, positioning it as an important agent for studies focused on heart function and related conditions. -
Beta 3 Receptor Agonist
BMS-194449 is a selective agonist for the beta-3 adrenergic receptor, exhibiting a binding affinity characterized by a Ki value of 160 nM. This compound is instrumental for research into metabolic disorders, particularly obesity and non-insulin dependent diabetes. Its activation of beta-3 receptors plays a critical role in regulating energy expenditure and lipid metabolism, making it a valuable tool for investigations in these areas. -
β-Adrenergic Receptor Blocker
Proxodolol is a β-adrenergic receptor blocker that inhibits β-adrenergic signaling pathways. It is primarily used in research to investigate its effects on arterial hypertension and related cardiovascular conditions. This compound serves as a valuable tool in studying the physiological implications of β-blockade in various therapeutic contexts. -
β2-AR Agonist
Arformoterol maleate is a long-acting β2-adrenergic receptor (β2-AR) agonist, with a half-maximal effective concentration (Kd) of 2.9 nM. This compound is primarily utilized in research related to chronic obstructive pulmonary disease (COPD), demonstrating significant bronchodilation and improving airflow in affected individuals. Its pharmacological properties make it valuable for studying respiratory diseases and the underlying mechanisms of β2-AR signaling. -
Adrenergic Receptor
Parethoxycaine hydrochloride is an anesthetic that acts primarily on the adrenergic receptors, exhibiting nerve conduction blocking activity. It demonstrates non-selective inhibitory effects on the responses of various stimulants in smooth muscle tissues, such as the rat vas deferens and guinea pig ileum. This compound also enhances the action of norepinephrine and its derivatives influence calcium transport processes, displaying distinct effects on calcium dose-response relationships. Parethoxycaine hydrochloride is valuable for research applications involving the modulation of adrenergic signaling and calcium dynamics in neuronal and smooth muscle systems. -
I2 Ligand
Metrazoline is an imidazoline I2 receptor ligand with low affinity for adrenergic receptors. This compound is used in research to study its role in modulating neuroprotective and antihypertensive effects. It serves as a valuable tool for investigating the physiological and pharmacological functions associated with imidazoline receptors in both in vitro and in vivo settings. -
4-Hydroxypropranolol Metabolite
(±)-4-Hydroxy propranolol β-D-glucuronide is a glucuronidated metabolite of the β-adrenergic receptor antagonist, 4-Hydroxypropranolol. It primarily serves as a marker for metabolic studies involving propranolol administration. This compound is valuable for research exploring drug metabolism, pharmacokinetics, and the therapeutic effects of β-blockers in cardiovascular studies. -
Adrenergic Receptor
(3aR,9aR)-Fluparoxan is a highly selective and potent antagonist of the α2B adrenergic receptor. This compound demonstrates significant potential in neurodevelopmental disorder and neurodegenerative disease research by promoting neurological recovery and function. Its unique mechanism of action positions (3aR,9aR)-Fluparoxan as a valuable tool in neuroscience studies, facilitating the exploration of related therapeutic pathways. -
α2-Adrenoceptor Ligand
TDIQ hydrochloride is a selective ligand for the α2-adrenergic receptors, exhibiting high affinity with Ki values of 75 nM, 95 nM, and 65 nM for the α2A, α2B, and α2C subtypes, respectively. This compound serves as a valuable tool for studying the physiological roles of α2-adrenoceptors and their potential therapeutic applications in various neuropsychiatric and cardiovascular disorders. Its specificity makes it suitable for pharmacological investigations and drug development in receptor-targeted therapies. -
Vasorelaxant Agent
Vasorelaxant agent-2 is an effective vasorelaxant agent that targets the α1A-adrenergic receptor, displaying an affinity of pD2=5.4. This compound demonstrates notable vasodilatory activity, evidenced by an EC50 of 0.79 μM in rat aortic rings. It is a valuable tool for research on vascular function and the modulation of blood pressure. -
α2-adrenoceptor Antagonist
A 80426 mesylate is an α2-adrenoceptor antagonist that modulates neurotransmitter release by inhibiting presynaptic α2-adrenergic receptors. This compound demonstrates potential in the study of antidepressant mechanisms and is utilized in research exploring mood disorders and anxiety. Its ability to enhance noradrenergic neurotransmission makes it a valuable tool for investigating therapeutic strategies within the central nervous system. -
Vasopressor
Mephentermine hemisulfate is a sympathomimetic amine that functions primarily as a vasopressor. It is utilized to increase blood pressure by stimulating adrenergic receptors, leading to vasoconstriction and increased heart rate. This compound has applications in cardiovascular research, particularly in studies related to blood pressure regulation and adrenergic signaling pathways. -
β Adrenergic Receptor Antagonist
Soquinolol is a selective β adrenergic receptor antagonist primarily used in cardiovascular research. This compound exhibits significant inhibition of β-adrenergic signaling, making it valuable for studying cardiac dysfunction and heart failure mechanisms. Its application extends to investigations into therapeutic strategies for managing hypertension and arrhythmias. -
ADRB2 Agonist
Mabuterol hydrochloride is a selective, orally active agonist of the beta-2 adrenergic receptor (ADRB2). This compound demonstrates key biological activity by inhibiting cell proliferation and reducing intracellular calcium levels induced by PDGF-BB. Additionally, Mabuterol hydrochloride downregulates protein expression of Drp-1, cyclin D1, and PCNA, while enhancing Mfn-2 expression in response to PDGF-BB. These properties make Mabuterol hydrochloride valuable for research in cellular signaling and related therapeutic applications. -
Platelet Aggregation Inhibitor
D-RGDW is a synthetic peptide containing the Arg-Gly-Asp (RGD) sequence, which targets the αIIbβ3 integrin. It effectively inhibits platelet aggregation, making it a valuable tool for research into thrombosis and hemostasis. D-RGDW can be utilized in various biochemical studies focused on vascular biology and the mechanisms of platelet activation. -
Glycoprotein IIb/IIIa Receptor/Platelet Aggregation Antagonist
Lamifiban TFA is a nonpeptide antagonist of the glycoprotein IIb/IIIa receptor, which plays a critical role in platelet aggregation. This compound effectively inhibits platelet aggregation and has shown potential in enhancing thrombolytic therapy to restore coronary arterial patency. Lamifiban TFA is a valuable tool for research in acute coronary syndromes and related cardiovascular conditions. -
Glycoprotein IIb/IIIa Receptor/Platelet Aggregation Antagonist
Lamifiban is a nonpeptide antagonist of the glycoprotein IIb/IIIa receptor, targeting platelet aggregation processes. It has demonstrated efficacy in restoring coronary arterial patency when used in combination with thrombolytic therapy. Lamifiban is a valuable compound for research focused on acute coronary syndromes and related cardiovascular conditions. -
Glycoprotein IIb-IIIa/Platelet Aggregation Inhibitor
Variabilin is a potent antagonist of glycoprotein IIb-IIIa, functioning primarily as a platelet aggregation inhibitor. Isolated from the hard tick Dermacentor variabilis, Variabilin effectively inhibits platelet aggregation induced by various agonists, including ADP, collagen, and thrombin receptor peptide SFLLRNP. Additionally, it hinders platelet adhesion to immobilized fibrinogen (Fg) and blocks the binding of purified human GPIIb-IIIa to immobilized Fg. This compound is valuable for research applications in hematology and thrombosis. -
CB1R/AMPK Modulator
CB1R/AMPK Modulator 1 is a potent modulator of the cannabinoid receptor type 1 (CB1R) and adenosine monophosphate-activated protein kinase (AMPK), exhibiting a Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound effectively activates AMPK, leading to significant reductions in food intake and body weight. Additionally, it enhances glucose tolerance and insulin sensitivity, making it a valuable tool for research in metabolic disorders and obesity-related studies. -
Dopamine β-hydroxylase Inhibitor
A32390A is a potent inhibitor of dopamine β-hydroxylase, functioning primarily to decrease norepinephrine synthesis. This reduction can lead to lowered blood pressure, making A32390A valuable in studies related to hypertension, particularly in models such as DOCA hypertensive rats. Additionally, the compound's properties as a copper chelator allow for exploration in the context of bacterial infections and metabolic disorders, providing versatile applications in chemical research. -
Fungal Metabolite
BE 24566B is a polyketide fungal metabolite that acts as an endothelin receptor antagonist, targeting both ETA and ETB receptors with IC50 values of 11 μM and 3.9 μM, respectively. This compound demonstrates antibacterial activity against a range of Gram-positive bacteria, including B. subtilis, B. cereus, S. aureus, M. luteus, E. faecalis, and S. thermophilus, with reported MICs of 1.56 μg/mL for five of these species and 3.13 μg/mL for E. faecalis and S. thermophilus. BE 24566B is valuable for research applications in antimicrobial studies and receptor pharmacology. -
AChE/Dopamine 2 Inhibitor
Itopride is a potent dopamine D2 receptor antagonist and an acetylcholinesterase (AChE) inhibitor. Itopride enhances gastric motility through its dual mechanisms of action, promoting both antidopaminergic and anti-acetylcholinesterase effects. This compound is primarily utilized in research related to gastrointestinal disorders, particularly gastroesophageal reflux disease (GERD), offering insights into prokinetic therapies. -
Phytocannabinoid Derivative
Cannabigerol diacetate is a phytocannabinoid derivative that modulates cannabinoid receptors in the endocannabinoid system. This compound exhibits potential anti-inflammatory and neuroprotective activities, making it an important tool for studying the therapeutic effects of cannabinoids. Its unique structural properties also allow for exploration in various research applications, including pain management and the effects of cannabinoids on neurological disorders. -
Cannabinoid Derivative
CH-FUBIATA is a synthetic cannabinoid derivative with a specific affinity for cannabinoid receptors. This compound demonstrates significant biological activity, impacting pathways involved in pain modulation, appetite regulation, and neuroprotection. CH-FUBIATA is applicable in research focusing on endocannabinoid system modulation, toxicological assessments, and the therapeutic potential of cannabinoids in various diseases. -
cannabinoid
Bzo-poxizid is a synthetic cannabinoid that primarily targets cannabinoid receptors in the central nervous system. This compound exhibits psychoactive properties, making it relevant for studies investigating endocannabinoid modulation and its effects on behavior. Bzo-poxizid may also be utilized in research applications focused on the therapeutic potential of cannabinoids in various neurological disorders. -
Cannabinoids Precursor
2-(2-Chlorophenyl)-1-(1H-indol-3-yl)ethanone is a key precursor in the synthesis of synthetic cannabinoids. This compound plays an essential role in the development of novel cannabinoid derivatives that may be used in pharmacological research. Its ability to modify cannabinoid structures makes it valuable for studies examining cannabinoid receptor interactions and their physiological effects. -
Cannabinoid-type Compounds
(±)-9-Nor-9α-hydroxy Hexahydrocannabinol is a cannabinoid-type compound that demonstrates significant cannabinoid-like activity in animal models, specifically in dogs and mice. This compound may be of interest for research exploring the therapeutic effects and pharmacological mechanisms of cannabinoids. Its efficacy in modulating cannabinoid receptors makes it a valuable tool for studies in areas such as pain relief, anxiety reduction, and other neuropsychopharmacological applications. -
Phytocannabinoid Metabolite
5'-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid metabolite that serves as a significant derivative of cannabinoids. It is known to exhibit potential psychoactive properties and interact with the endocannabinoid system. This compound may be utilized in research related to neuropharmacology, cannabinoid receptor studies, and the investigation of cannabis metabolites in biological systems. -
CB2 Receptor Ligand
Δ8-THC methyl ether is a selective ligand for the CB2 receptor, exhibiting a favorable docking score of -10.167 kcal/mol. This compound demonstrates significant antinociceptive activity in murine models, highlighting its potential for research in pain management and cannabinoid receptor studies. Further investigation into its pharmacological properties may support its application in the development of therapeutics targeting the endocannabinoid system. -
Cannabinoid Derivative
2-Fluoro QMPSB is a cannabinoid derivative that acts as a selective modulator of the cannabinoid receptors. This compound exhibits potent biological activity, making it useful for studying cannabinoid receptor mechanisms in research applications related to neuropharmacology and therapeutic developments. Its structural similarity to established synthetic cannabinoids provides valuable insights into cannabinoid receptor interactions and signaling pathways. -
Oxopyridine Carboxamide
CHO-4′Me-5′Br-FUBOXPYRA is an oxopyridine carboxamide that interacts with cannabinoid receptors CB1 and CB2. This compound exhibits limited activation potential, making it a valuable tool for studying the pharmacological properties of synthetic cannabinoids. Its unique structural features support research applications in cannabinoid receptor signaling and the development of cannabinoid-related therapies. -
Phytocannabinoid Derivative
(±)-9α-Hydroxy hexahydrocannabinol is a phytocannabinoid derivative that exhibits interactions with cannabinoid receptors in the endocannabinoid system. This compound has been explored for its potential therapeutic effects, including analgesic and anti-inflammatory properties. It serves as a valuable tool in research focused on understanding the pharmacological profiles of cannabinoids and their effects on various biological pathways. -
CB2 Receptor Agonist
PF-03550096 is an orally active synthetic cannabinoid that selectively targets peripheral CB2 receptors, exhibiting a Ki value of 7.9 nM. This compound demonstrates notable analgesic activity, making it useful for research applications related to pain modulation and inflammation. Its selective action on CB2 receptors enhances its potential for studying cannabinoid-based therapies in various physiological contexts. -
Cannabinoid Derivative
Afubiata is a cannabinoid derivative that interacts with the cannabinoid receptors in the endocannabinoid system. This compound exhibits potential biological activity related to modulating pain, inflammation, and neuroprotection. Afubiata is suitable for research applications focused on cannabinoid receptor mechanisms and the therapeutic effects of cannabinoids in various physiological processes. -
Phytocannabinoid Derivative
8(S)-Hydroxy-9(R)-hexahydrocannabinol is a phytocannabinoid derivative with a unique structural profile resembling known cannabinoids. This compound exhibits significant biological activity, including potential interaction with cannabinoid receptors, which makes it a valuable tool in cannabis research. It is applicable in studies investigating the therapeutic effects of cannabinoids, including pain relief and anti-inflammatory properties. -
Cannabinoid Derivative
(±)-9-Nor-9β-hydroxy Hexahydrocannabinol is a cannabinoid derivative that exhibits pronounced binding affinity for cannabinoid receptors. This compound is utilized in research to investigate the pharmacological effects of cannabinoids, including their influence on pain perception, appetite regulation, and neuroprotection. Its structural similarity to known synthetic cannabinoids makes it a valuable tool for studies focused on cannabinoid interactions and therapeutic potential. -
Cannabinoid Derivative
NAPIE is a cannabinoid derivative that modulates cannabinoid receptors. It exhibits significant biological activity in the endocannabinoid system, which is pivotal for studying the therapeutic potential of cannabinoids. NAPIE is primarily used in research applications related to neurobiology, pain management, and the exploration of cannabinoid signaling pathways. Its structural similarity to existing synthetic cannabinoids makes it a valuable tool for further investigations in cannabinoid biology. -
Cannabinoid Derivative
2-(1-(4-Fluorobenzyl)-1H-indol-3-yl)acetic acid is a cannabinoid derivative that interacts with cannabinoid receptors in the endocannabinoid system. This compound exhibits analgesic and anti-inflammatory properties, making it valuable for research in pain management and inflammation pathways. It serves as a useful tool in studying the pharmacological effects of cannabinoid-like substances.
