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Biological Activity
A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.08 mL | 80.42 mL | 160.84 mL |
| 0.5 mM | 3.22 mL | 16.08 mL | 32.17 mL |
| 1 mM | 1.61 mL | 8.04 mL | 16.08 mL |
| 5 mM | 0.32 mL | 1.61 mL | 3.22 mL |
*The above data is based on the productmolecular weight 621.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11288 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 869748-10-7 |
| Formula | C34H39N9O3 |
| M. Wt | 621.75 |
| Purity | >98% |
| Synonyms | A770041, A 770041 |
| SMILES | CC(=O)N1CCN(CC1)C2CCC(CC2)N3C4=C(C(=N3)C5=CC(=C(C=C5)NC(=O)C6=CC7=CC=CC=C7N6C)OC)C(=NC=N4)N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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