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Biological Activity
AAF-CMK is a serine protease inhibitor which irreversibly inhibits TPPII (tripeptidyl peptidase II), a giant protease which may substitute for some proteasome functions1, and reversibly inhibits Cln2 (TPPI).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.04 mL | 110.18 mL | 220.36 mL |
| 0.5 mM | 4.41 mL | 22.04 mL | 44.07 mL |
| 1 mM | 2.2 mL | 11.02 mL | 22.04 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.41 mL |
*The above data is based on the productmolecular weight 453.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13605 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 184901-82-4 |
| Formula | C16H22ClN3O3.CF3COOH |
| M. Wt | 453.8 |
| Purity | >98% |
| Synonyms | Tripeptidyl Peptidase Inhibitor II N-Ala-Ala-Phe-CMK |
| SMILES | C[C@@H](C(=O)NC(=O)[C@H](C)N[C@@H](CC1=CC=CC=C1)C(=O)CCl)N.C(=O)(C(F)(F)F)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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