ABT-199 (Venetoclax)

Catalog No.: A12500

Bcl-2 inhibitor

ABT-199 (Venetoclax) Chemical Structure

CAS NO. 1257044-40-8

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

Availability: In stock

Package Price Qty
10 mg
50 mg
100 mg
10mM * 1mL in DMSO

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay) Bcl-w (Cell-free assay) Mcl-1 (Cell-free assay)
444 nM(Ki)
In vitro (25°C) DMSO 100 mg/mL (115.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.51 mL 57.57 mL 115.15 mL
0.5 mM 2.3 mL 11.51 mL 23.03 mL
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL

*The above data is based on the productmolecular weight 868.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12500
Actions Inhibitor
M. Wt 868.44
Formula C45H50ClN7O7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1257044-40-8
Synonyms ABT199; ABT 199; GDC-0199; RG7601
SMILES CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

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