ABT-199 (Venetoclax)

Catalog No.: A12500

Bcl-2 inhibitor

ABT-199 (Venetoclax)

ABT-199 (Venetoclax) Chemical Structure

CAS NO. 1257044-40-8

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

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10 mg
50 mg
100 mg
10mM * 1mL in DMSO
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Martin Grundy, .et al. Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling, PLoS One, 2018, 13(1): e0190682 PMID: 29298347
  • Joanne Dai, .et al. Intracellular BH3 profiling reveals shifts in anti-apoptotic dependency in B-cell maturation and activation, J Immunol, 2018, 200 (5) 1727-1736 PMID: 29358277

Biological Activity

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay) Bcl-w (Cell-free assay) Mcl-1 (Cell-free assay)
444 nM(Ki)
In vitro (25°C) DMSO Warmed: 93 mg/mL (107.08 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+50% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.51 mL 57.57 mL 115.15 mL
0.5 mM 2.3 mL 11.51 mL 23.03 mL
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL

*The above data is based on the productmolecular weight 868.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12500
Actions Inhibitor
CAS No. 1257044-40-8
Formula C45H50ClN7O7S
M. Wt 868.44
Purity >98%
Synonyms ABT199; ABT 199; GDC-0199; RG7601
SMILES CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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