ABT-199 (Venetoclax)

Name: ABT-199 (Venetoclax)
SKU: A12500
Price: 56 USD
Rating: 5 (9 reviews)

Catalog No.: A12500

Bcl-2 inhibitor

Adooq's ABT-199 (Venetoclax) has been cited by 9 publications

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

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Grouped product items
Product Name	Price	Stock
ABT-199 10mg	Special Price $60.00 Regular Price $75.00	In stock
ABT-199 50mg	Special Price $80.00 Regular Price $100.00	In stock
ABT-199 100mg	Special Price $100.00 Regular Price $125.00	In stock
*ABT-199 10mM 1mL in DMSO**	Special Price $56.00 Regular Price $70.00	In stock
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Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper

Adooq's ABT-199 (Venetoclax) has been cited by 9 publications

Lindy Vernooij, .et al. , EJC Paediatric Oncology, 2024, 3: 100168

Tristen Wright, .et al. , Mol Cell, 2024, Apr 4;84(7):1338-1353 PMID: 38503284

Dilay Karademir, .et al. , Med Oncol, 2023, Jul 11;40(8):234 PMID: 37432531

Ashlyn Parkhurst, .et al. , Cell Death Dis, 2022, Apr 28;13(4):410 PMID: 35484114

Anna L Koessinger, .et al. , Cell Death Differ, 2022, Apr 26 PMID: 35473984

Florian J Bock, .et al. , Nat Commun, 2021, Nov 12;12(1):6572 PMID: 34772930

Chauhan D, .et al. , Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805

Martin Grundy, .et al. , PLoS One, 2018, 13(1): e0190682 PMID: 29298347

Joanne Dai, .et al. , J Immunol, 2018, 200 (5) 1727-1736 PMID: 29358277

Biological Activity

Discription

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

Targets

Target	Value

Product Information

Catalog Num	A12500
Formula	C45H50ClN7O7S
Molecular Weight	868.44
CAS Number	1257044-40-8
SMILES	CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
Synonyms	ABT199; ABT 199; GDC-0199; RG7601
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility

In vitro (25°C)	DMSO	Warmed: 93 mg/mL (107.08 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+50% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.51 mL	57.57 mL	115.15 mL
0.5 mM	2.3 mL	11.51 mL	23.03 mL
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL

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