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ABT-199 (Venetoclax)


Bcl-2 inhibitor

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Catalog No. A12500

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
ABT-199 10mg A12500-10

Regular Price: $120.00

Special Price: $108.00

ABT-199 25mg A12500-25

Regular Price: $250.00

Special Price: $225.00

ABT-199 50mg A12500-50

Regular Price: $520.00

Special Price: $468.00

ABT-199 100mg A12500-100

Regular Price: $800.00

Special Price: $720.00

ABT-199 10mM * 1mL in DMSO A12500-10mM-D

Regular Price: $163.00

Special Price: $146.70

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

ABT-199 (Venetoclax)

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Publications citing Adooq Products
ABT-199 (Venetoclax)  Citations (3)
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Martin Grundy, .et al. Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling, PLoS One, 2018, 13(1): e0190682 PMID: 29298347
  • Joanne Dai, .et al. Intracellular BH3 profiling reveals shifts in anti-apoptotic dependency in B-cell maturation and activation, J Immunol, 2018, 200 (5) 1727-1736 PMID: 29358277

Chemical Information

Catalog Num A12500
Actions Inhibitor
M. Wt 868.44
Formula C45H50ClN7O7S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1257044-40-8
Synonyms ABT199; ABT 199; GDC-0199; RG7601
SMILES CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C

Biological Activity

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay) Bcl-w (Cell-free assay) Mcl-1 (Cell-free assay)
444 nM(Ki)


Solubility (25°C) * In vitro DMSO 100 mg/mL (115.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.51 mL 57.57 mL 115.15mL
0.5 mM 2.3 mL 11.51 mL 23.03 mL
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL

*The above data is based on the productmolecular weight 868.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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