ACP-196 (Acalabrutinib)

Catalog No.: A15824

Btk Inhibitor

ACP-196 (Acalabrutinib) Chemical Structure

CAS NO. 1420477-60-6

ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.

Availability: In stock

Package Price Qty
5 mg

Regular Price: $50.00

Special Price $40.00

10 mg

Regular Price: $70.00

Special Price $56.00

25 mg

Regular Price: $100.00

Special Price $80.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.
Targets
BTK
3nM
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.48 mL 107.41 mL 214.81 mL
0.5 mM 4.3 mL 21.48 mL 42.96 mL
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL

*The above data is based on the productmolecular weight 465.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15824
Actions Inhibitor
M. Wt 465.52
Formula C26H23N7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1420477-60-6
Synonyms Acalabrutinib, ACP196, ACP 196
SMILES CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5

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