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Biological Activity
ACP-196 is an orally available inhibitor of Bruton‘s tyrosine kinase (BTK) with potential antineoplastic activity. It inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway.
Targets
| BTK | ||||
| 3nM |
| In vitro (25°C) | DMSO | 80 mg/mL (171.85 mM) | |
| Water | Insoluble | ||
| Ethanol | 80 mg/mL (171.85 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 5 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.48 mL | 107.41 mL | 214.81 mL |
| 0.5 mM | 4.3 mL | 21.48 mL | 42.96 mL |
| 1 mM | 2.15 mL | 10.74 mL | 21.48 mL |
| 5 mM | 0.43 mL | 2.15 mL | 4.3 mL |
*The above data is based on the productmolecular weight 465.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15824 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1420477-60-6 |
| Formula | C26H23N7O2 |
| M. Wt | 465.52 |
| Purity | >98% |
| Synonyms | Acalabrutinib, ACP196, ACP 196 |
| SMILES | CC#CC(=O)N1CCCC1C2=NC(=C3N2C=CN=C3N)C4=CC=C(C=C4)C(=O)NC5=CC=CC=N5 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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