AKB-6899 is a selective HIF-2α stabilizer that functions as a prolyl hydroxylase domain 3 (PHD3) inhibitor. This compound enhances the production of the soluble form of the VEGF receptor (sVEGFR-1) in GM-CSF-treated macrophages. AKB-6899 exhibits notable antitumor and antiangiogenic properties, making it valuable for research applications focused on cancer biology and vascular biology.
AKB-6899 is a selective HIF-2α stabilizer that functions as a prolyl hydroxylase domain 3 (PHD3) inhibitor. This compound enhances the production of the soluble form of the VEGF receptor (sVEGFR-1) in GM-CSF-treated macrophages. AKB-6899 exhibits notable antitumor and antiangiogenic properties, making it valuable for research applications focused on cancer biology and vascular biology.
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