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Biological Activity
Altiratinib is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling, cell growth and migration as compared with a HGF antagonist in vitro.
| In vitro | DMSO | 99 mg/mL (193.94 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.59 mL | 97.95 mL | 195.9 mL |
| 0.5 mM | 3.92 mL | 19.59 mL | 39.18 mL |
| 1 mM | 1.96 mL | 9.8 mL | 19.59 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
*The above data is based on the productmolecular weight 510.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14387 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1345847-93-9 |
| Formula | C26H21F3N4O4 |
| M. Wt | 510.46 |
| Purity | >98% |
| Synonyms | DCC-2701, DCC2701, DCC 2701, DP 5164, DP5164, DP-5164 |
| SMILES | FC1=CC=C(NC(C2(C(NC3=C(F)C=C(OC4=CC(/N=C(O)/C5CC5)=NC=C4)C(F)=C3)=O)CC2)=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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