Catalog No.: A18360

MCL-1 inhibitor


AMG-176 Chemical Structure

CAS NO. 1883727-34-1

AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.

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Biological Activity

AMG-176 is a potent, selective and orally bioavailable MCL-1 inhibitor, with a Ki of 0.13 nM.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.31 mL 81.54 mL 163.08 mL
0.5 mM 3.26 mL 16.31 mL 32.62 mL
1 mM 1.63 mL 8.15 mL 16.31 mL
5 mM 0.33 mL 1.63 mL 3.26 mL

*The above data is based on the productmolecular weight 613.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A18360
Actions Inhibitor
CAS No. 1883727-34-1
Formula C33H41ClN2O5S
M. Wt 613.21
Purity >98%
Synonyms AMG-176; AMG 176; AMG176; tapotoclax; tapotoclaxum.
SMILES CO[[email protected]]1\C=C\C[[email protected]](C)[[email protected]@H](C)S(=O)(=O)NC(=O)c2ccc3OC[[email protected]]4(CCCc5cc(Cl)ccc45)CN(C[[email protected]@H]6CC[[email protected]@H]16)c3c2

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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