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Biological Activity
AMG 232 is a highly potent, selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction((SPR KD= 0.045 nM, SJSA-1 EdU IC50=9.1 nM).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.59 mL | 87.94 mL | 175.89 mL |
| 0.5 mM | 3.52 mL | 17.59 mL | 35.18 mL |
| 1 mM | 1.76 mL | 8.79 mL | 17.59 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
*The above data is based on the productmolecular weight 568.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14394 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1352066-68-2 |
| Formula | C28H35Cl2NO5S |
| M. Wt | 568.55 |
| Purity | >98% |
| Synonyms | AMG-232, AMG 232 |
| SMILES | CC(C)[[email protected]@H](CS(=O)(=O)C(C)C)N1[[email protected]@H]([[email protected]](C[[email protected]](C1=O)(C)CC(=O)O)C2=CC(=CC=C2)Cl)C3=CC=C(C=C3)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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