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Amidate-VC-PAB-MMAF

Catalog No.: A41506
Drug-Linker Conjugates for ADC
Amidate-VC-PAB-MMAF is a cleavable drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound combines the Amidate-VC-PAB linker with MMAF, a potent inhibitor of tubulin polymerization, to enhance the targeted delivery of therapeutic agents. By utilizing this linker, researchers can minimize off-target cytotoxicity while improving the efficacy of ADCs in cancer treatments and other applications in drug development.
Amidate-VC-PAB-MMAF 2202782-90-7 Drug-Linker Conjugates for ADC
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAmidate-VC-PAB-MMAF is a cleavable drug-linker conjugate designed for use in antibody-drug conjugates (ADCs). This compound combines the Amidate-VC-PAB linker with MMAF, a potent inhibitor of tubulin polymerization, to enhance the targeted delivery of therapeutic agents. By utilizing this linker, researchers can minimize off-target cytotoxicity while improving the efficacy of ADCs in cancer treatments and other applications in drug development.
Product Information
Catalog NumA41506
FormulaC69H102N11O16P
Molecular Weight1372.59
CAS Number2202782-90-7
SMILESC[C@@H](C(N[C@H](C(O)=O)CC1=CC=CC=C1)=O)[C@H]([C@@](CCC2)([H])N2C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(C(C=C4)=CC=C4N[P](OCC)(C#C)=O)=O)=O)=O)=O)=O)=O)=O)OC
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Antibody-drug Conjugates (ADC) > Drug-Linker Conjugates for ADC