AP22408 is a potent nonpeptide inhibitor of the Src SH2 domain, exhibiting an IC50 value of 0.3 μM. This compound effectively inhibits osteoclast-mediated resorption of dentine in rabbits and demonstrates strong bone-targeting properties. In vivo studies reveal its antiresorptive activity in a parathyroid hormone-induced rat model, indicating potential applications in osteoporosis research and other bone-related diseases, including Paget’s disease, osteolytic bone metastasis, and malignancy-associated hypercalcemia.
AP22408 is a potent nonpeptide inhibitor of the Src SH2 domain, exhibiting an IC50 value of 0.3 μM. This compound effectively inhibits osteoclast-mediated resorption of dentine in rabbits and demonstrates strong bone-targeting properties. In vivo studies reveal its antiresorptive activity in a parathyroid hormone-induced rat model, indicating potential applications in osteoporosis research and other bone-related diseases, including Paget’s disease, osteolytic bone metastasis, and malignancy-associated hypercalcemia.
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